Faculty of Medicine,
The Chinese University of Hong Kong

Dr. Hao SU

Postdoctoral researcher

Dr. Hao SU

Ph.D.

Postdoctoral Fellow

Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

My current research interest are Gut Microbiome, m6A, and Colorectal Cancer.

Publications:

For details about citations arising from my publications and links to online versions of some of the publications, refer to:

https://orcid.org/0000-0002-7621-8730

(^co-first author, *corresponding author or senior author)

  • Gou H, Wong CC, Chen H, Shang H, Su H, Zhai J, Liu W, Liu W, Sun D, Wang X, Yu J. TRIP6 disrupts tight junctions to promote metastasis and drug resistance and is a therapeutic target in colorectal cancer. Cancer Lett. 2023 Dec 1;578:216438. doi: 10.1016/j.canlet.2023.216438. Epub 2023 Oct 11. PMID: 37827326.
 
  • Gou H#, Su H#, Liu D#, Wong CC, Shang H, Fang Y, Zeng X, Chen H, Li Y, Huang Z, Fan M, Wei C, Wang X, Zhang X, Li X, Yu J. Traditional Medicine Pien Tze Huang Suppresses Colorectal Tumorigenesis Through Restoring Gut Microbiota and Metabolites. Gastroenterology. 2023 Dec;165(6):1404-1419. doi: 10.1053/j.gastro.2023.08.052. Epub 2023 Sep 12. PMID: 37704113.
 
  • Zhou Q, Peng Y, Ji F, Chen H, Kang W, Chan LS, Gou H, Lin Y, Huang P, Chen D, Wei Q, Su H, Liang C, Zhang X, Yu J, Wong CC. Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer. Nat Commun. 2023 Aug 4;14(1):4677. doi: 10.1038/s41467-023-39571-6. PMID: 37542037; PMCID: PMC10403583.
 
  • Su H, Cheung H, Lau HC, Chen H, Zhang X, Qin N, Wang Y, Chan MTV, Wu WKK, Chen H. Crosstalk between gut microbiota and RNA N6-methyladenosine modification in cancer. FEMS Microbiol Rev. 2023 Jul 5;47(4):fuad036. doi: 10.1093/femsre/fuad036. PMID: 37407433.
 
  • Wang X, Wong CC, Chen H, Fu K, Shi L, Su H, Guo S, Gou H, Hu X, Zhang L, Ji J, Yu J. The N6-methyladenine DNA demethylase ALKBH1 promotes gastric carcinogenesis by disrupting NRF1 binding capacity. Cell Rep. 2023 Mar 28;42(3):112279. doi: 10.1016/j.celrep.2023.112279. Epub 2023 Mar 22. PMID: 36989111.
 
  • Chen H, Zhang X, Su H, Zeng J, Chan H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV, Chen H. Immune dysregulation and RNA N6-methyladenosine modification in sepsis. Wiley Interdiscip Rev RNA. 2023 May-Jun;14(3):e1764. doi: 10.1002/wrna.1764. Epub 2022 Sep 23. PMID: 36149809.
  • Zhang X, Su H, Chen H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV, Chen H. RNA Modifications in Gastrointestinal Cancer: Current Status and Future Perspectives. Biomedicines. 2022 Aug 8;10(8):1918. doi: 10.3390/biomedicines10081918. PMID: 36009465; PMCID: PMC9405978.
 
  • Chen H, Wang Y, Su H, Zhang X, Chen H, Yu J. RNA N6-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness. Front Cell Dev Biol. 2022 Jul 4;10:935224. doi: 10.3389/fcell.2022.935224. PMID: 35859892; PMCID: PMC9289108.
 
  • Wong CC, Wu JL, Ji F, Kang W, Bian X, Chen H, Chan LS, Luk STY, Tong S, Xu J, Zhou Q, Liu D, Su H, Gou H, Cheung AH, To KF, Cai Z, Shay JW, Yu J. The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer. Nat Commun. 2022 Jul 8;13(1):3971. doi: 10.1038/s41467-022-31663-z. PMID: 35803966; PMCID: PMC9270407.
 
  • Chen H, Pan Y, Zhou Q, Liang C, Wong CC, Zhou Y, Huang D, Liu W, Zhai J, Gou H, Su H, Zhang X, Xu H, Wang Y, Kang W, Kei Wu WK, Yu J. METTL3 Inhibits Antitumor Immunity by Targeting m6A-BHLHE41-CXCL1/CXCR2 Axis to Promote Colorectal Cancer. Gastroenterology. 2022 Oct;163(4):891-907. doi: 10.1053/j.gastro.2022.06.024. Epub 2022 Jun 11. PMID: 35700773.
  • Liu W, Gou H, Wang X, Li X, Hu X, Su H, Li S, Yu J. TTPAL promotes gastric tumorigenesis by directly targeting NNMT to activate PI3K/AKT signaling. Oncogene. 2021 Dec;40(49):6666-6679. doi: 10.1038/s41388-021-01838-x. Epub 2021 Oct 12. PMID: 34642500; PMCID: PMC8660633.
 
  • Liu D, Wong CC, Zhou Y, Li C, Chen H, Ji F, Go MYY, Wang F, Su H, Wei H, Cai Z, Wong N, Wong VWS, Yu J. Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target. Gastroenterology. 2021 Jun;160(7):2467-2482.e3. doi: 10.1053/j.gastro.2021.02.051. Epub 2021 Feb 27. Erratum in: Gastroenterology. 2022 Aug;163(2):536. doi: 10.1053/j.gastro.2022.06.018. PMID: 33647280.
 
  • Chen H, Gao S, Liu W, Wong CC, Wu J, Wu J, Liu D, Gou H, Kang W, Zhai J, Li C, Su H, Wang S, Soares F, Han J, He HH, Yu J. RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target. Gastroenterology. 2021 Mar;160(4):1284-1300.e16. doi: 10.1053/j.gastro.2020.11.013. Epub 2020 Nov 18. PMID: 33217448.
  • Mei Y, Liu B, Su H, Zhang H, Liu F, Ke Q, Sun X, Tan W. Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC-1α pathway. J Cell Mol Med. 2020 Sep;24(18):10866-10875. doi: 10.1111/jcmm.15715. Epub 2020 Aug 5. PMID: 32757458; PMCID: PMC7521233.
 
  • Liu F, Su H, Liu B, Mei Y, Ke Q, Sun X, Tan W. STVNa Attenuates Isoproterenol-Induced Cardiac Hypertrophy Response through the HDAC4 and Prdx2/ROS/Trx1 Pathways. Int J Mol Sci. 2020 Jan 20;21(2):682. doi: 10.3390/ijms21020682. PMID: 31968660; PMCID: PMC7014432.
  • Chen Y, Beng H, Su H, Han F, Fan Z, Lv N, Jovanović A, Tan W. Isosteviol prevents the development of isoprenaline‑induced myocardial hypertrophy. Int J Mol Med. 2019 Nov;44(5):1932-1942. doi: 10.3892/ijmm.2019.4342. Epub 2019 Sep 17. PMID: 31545484; PMCID: PMC6777692.
 
  • Beng H, Su H, Wang S, Kuai Y, Hu J, Zhang R, Liu F, Tan W. Differential effects of inhaled R- and S-terbutaline in ovalbumin-induced asthmatic mice. Int Immunopharmacol. 2019 Aug;73:581-589. doi: 10.1016/j.intimp.2019.04.036. Epub 2019 Jun 21. PMID: 31234092.
  • Li Q, Zhan S, Liu Q, Su H, Dai X, Wang H, Beng H, Tan W. Preparation of a Sustained-Release Nebulized Aerosol of R-terbutaline Hydrochloride Liposome and Evaluation of Its Anti-asthmatic Effects via Pulmonary Delivery in Guinea Pigs. AAPS PharmSciTech. 2018 Jan;19(1):232-241. doi: 10.1208/s12249-017-0816-z. Epub 2017 Jul 5. PMID: 28681333.
  • Su H, Pistolozzi M, Shi X, Sun X, Tan W. Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy. Acta Biochim Biophys Sin (Shanghai). 2017 Nov 1;49(11):1022-1028. doi: 10.1093/abbs/gmx102. PMID: 29036266.

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