Faculty of Medicine,
The Chinese University of Hong Kong

Dr. ZENG Judeng

Postdoctoral researcher

Dr. ZENG Judeng

BSc (Hons), MPhil, PhD

Scientific Officer

Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

My current research interests are in m6A modification, Autophagy, Helicobacter pylori infection

Publications:

  • Zeng, J.#, Xie, C#., Huang, Z., Cho, C. H., Chan, H., Li, Q., Ashktorab, H., Smoot, D. T., Wong, S. H., Yu, J., Gong, W., Liang, C., Xu, H., Chen, H., Liu, X., Wu, J. C. Y., Ip, M., Gin, T., Zhang, L., Chan, M. T. V., Hu, W., & Wu, W. K. K. (2024). LOX-1 acts as an N6-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase. Nat Commun, 15(1), 669. [IF2023=14.7]
  • Chen, M., Fang, Y., Liang, M., Zhang, N., Zhang, X., Xu, L., Ren, X., Zhang, Q., Zhou, Y., Peng, S., Yu, J., Zeng, J.*, & Li, X*. (2023). The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma. J Transl Med, 21(1), 276. [IF2023=6.1]
 
  • Chen, H., Zhang, X., Su, H., Zeng, J., Chan, H., Li, Q., Liu, X., Zhang, L., Wu, W.K.K., Chan, M.T.V., and Chen, H. (2023). Immune dysregulation and RNA N6-methyladenosine modification in sepsis. Wiley Interdiscip Rev RNA, e1764. 10.1002/wrna.1764. [IF2023=6.4]
  • Zeng, J., Xie, C., Zhang, L., Liu, X., Chan, M.T.V., Wu, W.K.K., and Chen, H. (2022). Host Cell Antimicrobial Responses against Helicobacter pylori Infection: From Biological Aspects to Therapeutic Strategies. Int J Mol Sci 23. 10.3390/ijms231810941. [IF2023=4.9]
 
  • Wang, X., Hu, W., Li, X., Huang, D., Li, Q., Chan, H., Zeng, J., Xie, C., Chen, H., Liu, X., Gin, T., Wang, M.H., Cheng, A.S.L., Kang, W., To, K.F., Plewczynski, D., Zhang, Q., Chen, X., Chan, D.C.W., Ko, H., Wong, S.H., Yu, J., Chan, M.T.V., Zhang, L., and Wu, W.K.K. (2022). Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution. Cancer research 82, 1482-1491. [IF2023=12.5]
 
  • Sun, X., Liu, Y., Huang, Z., Xu, W., Hu, W., Yi, L., Liu, Z., Chan, H., Zeng, J., Liu, X., Chen, H., Yu, J., Chan, F.K.L., Ng, S.C., Wong, S.H., Wang, M.H., Gin, T., Joynt, G.M., Hui, D.S.C., Zou, X., Shu, Y., Cheng, C.H.K., Fang, S., Luo, H., Lu, J., Chan, M.T.V., Zhang, L., and Wu, W.K.K. (2022). SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1. Cell Death Differ 29, 1240-1254. [IF2023=13.7]
 
  • Chan, H., Li, Q., Wang, X., Liu, W.Y., Hu, W., Zeng, J., Xie, C., Kwong, T.N.Y., Ho, I.H.T., Liu, X., Chen, H., Yu, J., Ko, H., Chan, R.C.Y., Ip, M., Gin, T., Cheng, A.S.L., Zhang, L., Chan, M.T.V., Wong, S.H., and Wu, W.K.K. (2022). Vitamin D(3) and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification. Autophagy 18, 2050-2067. [IF2023=14.6]
  • Wang, X., Chen, M., Liang, X., Bai, Y., Zeng, J., Xu, X., Li, H., Wang, J., Fan, K., and Zhao, G. (2021). RNF135 Promoter Methylation Is Associated With Immune Infiltration and Prognosis in Hepatocellular Carcinoma. Front Oncol 11, 752511. [IF2023=3.5]
 
  • Li, Q., Hu, W., Liu, W.X., Zhao, L.Y., Huang, D., Liu, X.D., Chan, H., Zhang, Y., Zeng, J.D., Coker, O.O., Kang, W., Ng, S.S.M., Zhang, L., Wong, S.H., Gin, T., Chan, M.T.V., Wu, J.L., Yu, J., and Wu, W.K.K. (2021). Streptococcus thermophilus Inhibits Colorectal Tumorigenesis Through Secreting beta-Galactosidase. Gastroenterology 160, 1179-1193. [IF2023=25.7]
  • Ho, J., Chan, H., Liang, Y., Liu, X., Zhang, L., Li, Q., Zhang, Y., Zeng, J., Ugwu, F.N., Ho, I.H.T., Hu, W., Yau, J.C.W., Wong, S.H., Wong, W.T., Ling, L., Cho, C.H., Gallo, R.L., Gin, T., Tse, G., Yu, J., Chan, M.T.V., Leung, C.C.H., and Wu, W.K.K. (2020). Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. Crit Care 24, 47. [IF2023=8.8]
  • Zeng, J.D., Wu, W.K.K., Wang, H.Y., and Li, X.X. (2019). Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer. Pharmacol Res, 104352. [IF2023=9.1]
  • Zeng, J.D., Zhang, N., Zhao, G.J., Xu, L.X., Yang, Y., Xu, X.Y., Chen, M.K., Wang, H.Y., Zheng, S.X., and Li, X.X. (2018). MT1G is Silenced by DNA Methylation and Contributes to the Pathogenesis of Hepatocellular Carcinoma. J Cancer 9, 2807-2816. [IF2023=3.3]
 
  • Zeng, L., Liao, Q., Zou, Z., Wen, Y., Wang, J., Liu, C., He, Q., Weng, N., Zeng, J., Tang, H., Fang, R., Lei, Z., Tang, Z., Yang, X., and Cui, S. (2018). Long Non-Coding RNA XLOC_006753 Promotes the Development of Multidrug Resistance in Gastric Cancer Cells Through the PI3K/AKT/mTOR Signaling Pathway. Cell Physiol Biochem 51, 1221-1236. [IF2023=2.5]
  • Jiang, C., Xu, R., Li, X.X., Wang, Y.Y., Liang, W.Q., Zeng, J.D., Zhang, S.S., Xu, X.Y., Yang, Y., Zhang, M.Y., Wang, H.Y., and Zheng, X.F.S. (2017). p53R2 overexpression in cervical cancer promotes AKT signaling and EMT, and is correlated with tumor progression, metastasis and poor prognosis. Cell cycle (Georgetown, Tex.) 16, 1673-1682. [IF2023=3.4]

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