Faculty of Medicine,
The Chinese University of Hong Kong

Prof. TAN Likai

Professor

Prof. TAN Likai

PhD in Immunology

Research Assistant Professor (Non-clinical)
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

My research interests are primarily to understand the differentiation, residency and dynamics of αβ T and γδ T cells using systems biology approaches, that includes single-cell multi-omics, TCR-sequencing, high-dimensional flow cytometry, spatial transcriptome and other novel mechanisms.

Prof. TAN Likai

Publications

Google scholar → https://scholar.google.com.hk/citations?user=2_WNZoAAAAAJ

ORCID → https://orcid.org/0000-0001-7555-9472

Research gate → https://www.researchgate.net/profile/Likai-Tan

But my twitter is more fun! → https://twitter.com/likai_tan


  • Song, Z., Henze, L., Casar, C., Schwinge, D., Schramm, C., Fuss, J., Tan, L*. & Prinz, I*. Human gammadelta T cell Identification from Single-cell RNA Sequencing Datasets by Modular TCR Expression. J Leukoc Biol (2023)
 
  •   Marzano, P., Balin, S., Terzoli, S., Della Bella, S., Cazzetta, V., Piazza, R., Sandrock, I., Ravens, S., Tan, L. K., Prinz, I., Calcaterra, F., Di Vito, C., Cancellara, A., Calvi, M., Carletti, A., Franzese, S., Frigo, A., Darwish, A., Voza, A., Mikulak, J. & Mavilio, D. Transcriptomic profile of MAIT cells is linked to B cell response following SARS-CoV-2 vaccination. Frontiers in Immunology 14 (2023)
 
  •   Hahn, A. M., Vogg, L., Brey, S., Schneider, A., Schäfer, S., Palmisano, R., Pavlova, A., Sandrock, I., Tan, L. K., Fichtner, A. S., Prinz, I., Ravens, S. & Winkler, T. H. A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (vol 42, 112253, 2023). Cell Reports 42 (2023)
  • Tan, L#., Inácio, D#., Prinz, I. & Silva-Santos, B. New insights on murine γδ T cells from single-cell multi-omics. Science Bulletin 67, 1102-1104 (2022)
 
  • Deseke, M., Rampoldi, F., Sandrock, I., Borst, E., Boning, H., Ssebyatika, G. L., Jurgens, C., Pluckebaum, N., Beck, M., Hassan, A., Tan, L., Demera, A., Janssen, A., Steinberger, P., Koenecke, C., Viejo-Borbolla, A., Messerle, M., Krey, T. & Prinz, I. A CMV-induced adaptive human Vdelta1+ gammadelta T cell clone recognizes HLA-DR. J Exp Med 219 (2022)
 
  • Deng, L., Harms, A., Ravens, S., Prinz, I*. & Tan, L*. Systematic pattern analyses of Vδ2+ TCRs reveal that shared “public” Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status. Frontiers in Immunology 13 (2022)
 
  • Chen, Y., Yan, S.-M., Pu, Z., Feng, J., Tan, L., Li, Y., Hu, H., Huang, W., Lin, Y. & Peng, Z. Dopamine signaling promotes tissue-resident memory differentiation of CD8+ T cells and antitumor immunity. Cancer Research 82, 3130-3142 (2022)
  • Zhu, S., Stanslowsky, N., Fernandez-Trillo, J., Mamo, T. M., Yu, P., Kalmbach, N., Ritter, B., Eggenschwiler, R., Ouwendijk, W. J. D., Mzinza, D., Tan, L., Leffler, A., Spohn, M., Brown, R. J. P., Kropp, K. A., Kaever, V., Ha, T. C., Narayanan, P., Grundhoff, A., Forster, R., Schambach, A., Verjans, G., Schmidt, M., Kispert, A., Cantz, T., Gomis, A., Wegner, F. & Viejo-Borbolla, A. Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2. Stem Cell Res 56, 102535 (2021)
 
  •   Zhang, Y., Hu, H., Liu, W., Yan, S.-M., Li, Y., Tan, L., Chen, Y., Liu, J., Peng, Z. & Yuan, Y. Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity. Journal for immunotherapy of cancer 9 (2021)
  •   Tan, L#., Fichtner, A. S#., Bruni, E., Odak, I., Sandrock, I., Bubke, A., Borchers, A., Schultze-Florey, C., Koenecke, C., Förster, R., Jarek, M., von Kaisenberg, C., Schulz, A., Chu, X., Zhang, B., Li, Y., Panzer, U., Krebs, C. F., Ravens, S. & Prinz, I. A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood. Science Immunology 6, eabf0125-eabf0125 (2021)
  •   Schultze-Florey, C. R., Kuhlmann, L., Raha, S., Barros-Martins, J., Odak, I., Tan, L., Xiao, Y., Ravens, S., Hambach, L. & Venturini, L. Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI. Blood advances 5, 4485-4499 (2021)
  •   Cazzetta, V., Bruni, E., Terzoli, S., Carenza, C., Franzese, S., Piazza, R., Marzano, P., Donadon, M., Torzilli, G., Cimino, M., Simonelli, M., Bello, L., Villa, A., Tan, L., Ravens, S., Prinz, I., Supino, D., Colombo, F. S., Lugli, E., Marcenaro, E., Vivier, E., Della Bella, S., Mikulak, J. & Mavilio, D. NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions. Cell Reports 37, 109871 (2021)
  • Fichtner, A. S., Bubke, A., Rampoldi, F., Wilharm, A., Tan, L., Steinbrück, L., Schultze‐Florey, C., Kaisenberg, C., Prinz, I., Herrmann, T. & Ravens, S. TCR repertoire analysis reveals phosphoantigen‐induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults. Journal of Leukocyte Biology 107, 1023-1032 (2020)
 
  •   1Eckert, N., Werth, K., Willenzon, S., Tan, L. & Förster, R. B cell hyperactivation in an Ackr4 ‐deficient mouse strain is not caused by lack of ACKR4 expression. Journal of Leukocyte Biology 107, 1155-1166 (2020)
  • Tan, L. #, Sandrock, I. #, Odak, I., Aizenbud, Y., Wilharm, A., Barros-Martins, J., Tabib, Y., Borchers, A., Amado, T., Gangoda, L., Herold, M. J., Schmidt-Supprian, M., Kisielow, J., Silva-Santos, B., Koenecke, C., Hovav, A. H., Krebs, C., Prinz, I., Ravens, S., others, Herold, M. J., Schmidt-Supprian, M., Kisielow, J., Silva-Santos, B., Koenecke, C., Hovav, A. H., Krebs, C., Prinz, I., Ravens, S. & others. Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells. Cell Reports 27, 3657-3671 (2019)
  • Sandrock, I., Reinhardt, A., Ravens, S., Binz, C., Wilharm, A., Martins, J., Oberdorfer, L., Tan, L., Lienenklaus, S., Zhang, B., Naumann, R., Zhuang, Y., Krueger, A., Forster, R. & Prinz, I. Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing gammadelta T cells. J Exp Med 215, 3006-3018 (2018)
 
  • Pan, T., Peng, Z., Tan, L., Zou, F., Zhou, N., Liu, B., Liang, L., Chen, C., Liu, J., Wu, L., Liu, G., Peng, Z., Liu, W., Ma, X., Zhang, J., Zhu, X., Liu, T., Li, M., Huang, X., Tao, L., Zhang, Y. & Zhang, H. Nonsteroidal Anti-inflammatory Drugs Potently Inhibit the Replication of Zika Viruses by Inducing the Degradation of AXL. Journal of Virology (2018)
  • Zhang, J., Huang, F., Tan, L., Bai, C., Chen, B., Liu, J., Liang, J., Liu, C., Zhang, S., Lu, G., Chen, Y. & Zhang, H. Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein. Journal of Virology (2016)
 
  • Liu, J., Huang, F., Zhang, J., Tan, L., Lu, G., Zhang, X. & Zhang, H. Characteristic amino acid changes of influenza A (H1N1) pdm09 virus PA protein enhance A (H7N9) viral polymerase activity. Virus genes 52, 346-353 (2016)
Year 2014
  • Zhou, H., Cao, Z., Tan, L., Fu, X., Lu, G., Qi, W., Ke, C., Wang, H., Sun, L. & Zhang, G. Avian-like A (H1N1) swine influenza virus antibodies among swine farm residents and pigs in southern China. Japanese Journal of Infectious Diseases 67, 184-190 (2014)
  • Tan, L., Su, S., Smith, D. K., He, S., Zheng, Y., Shao, Z., Ma, J., Zhu, H. & Zhang, G. A Combination of HA and PA Mutations Enhances Virulence in a Mouse-Adapted H6N6 Influenza A Virus. Journal of Virology 88, 14116-14125 (2014)
  Year 2013
  • Zhang, Y.-B., Chen, J.-D., Xie, J.-X., Zhu, W.-J., Wei, C.-Y., Tan, L.-K., Cao, N., Chen, Y., Zhang, M.-Z. & Zhang, G.-H. Serologic reports of H3N2 canine influenza virus infection in dogs in northeast China. Journal of Veterinary Medical Science 75, 1061-1062 (2013)
  • Wang, H., Jia, K., Qi, W., Zhang, M., Sun, L., Liang, H., Du, G., Tan, L., Shao, Z. & Ye, J. Genetic characterization of avian-origin H3N2 canine influenza viruses isolated from Guangdong during 2006–2012. Virus Genes 46, 558-562 (2013)
  • Su, S., Ning, Z., Zhu, W., Jiao, P., Ke, C., Qi, W., Huang, Z., Tian, J., Cao, L. & Tan, L. Lack of evidence of avian-to-human transmission of avian influenza A (H5N1) virus among veterinarians, Guangdong, China, 2012. Journal of Clinical Virology 56, 365-366 (2013)
  • Cao, N., Zhu, W., Chen, Y., Tan, L., Zhou, P., Cao, Z., Ke, C., Li, Y., Wu, J. & Qi, W. Avian influenza A (H5N1) virus antibodies in pigs and residents of swine farms, southern China. Journal of Clinical Virology 58, 647-651 (2013)

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