Faculty of Medicine,
The Chinese University of Hong Kong

Prof. LIU Xiaodong

Professor

Prof. LIU Xiaodong

BSc, MPhil, PhD

Research Assistant Professor (Non-clinical)
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

My research interests are in Pain neurocircuitry; Chronic pain mechanisms; Sepsis; Autophagy

Prof. LIU Xiaodong

Publications

For details about citations arising from my publications and links to online versions of some of the publications, refer to:
https://publons.com/researcher/1633858/xiaodong-liu/

(*corresponding author, ^co-first author)


  • Gan X, Peng B, Chen L, Jiang Y, Li T, Li B, Liu X (2023) Identification of xanthine oxidase inhibitors from celery seeds using affinity ultrafiltration-liquid chromatography-mass spectrometry. Molecules 28:6048.
 
  • Shu Y, Peng F, Zhao B, Liu C, Li Q, Li H, Wang Y, Jiang Y, Lu T, Wang Q, Sun J, Feng H, Lu Z, Liu X*, Wang J, Qiu W (2023) Transfer of patient’s peripheral blood mononuclear cells (PBMCs) disrupts blood-brain barrier and induces anti-NMDAR encephalitis: a study of novel humanized PBMC mouse model. J Neuroinflammation 20:164.
 
  • Sun W, Hao Y, Li R, Ho HT, Wu S, Li N, Ba X, Wang J, Xiong D, Jiang C, Xiao L, Liu X* (2023) Comparative transcriptome of dorsal root ganglia reveals distinct etiologies of paclitaxel- and oxaliplatin-induced peripheral neuropathy in rats. Neuroscience 516:1-14.
 
  • Ren Z, Song Y, Xian J, Liao Y, Zhan Y, Zhao T, Wang H, Jiang J, Xu M, Jiang Y, Liu X, Wei X, Wang K, Xiao J (2023) Identification of Fangchinoline as a novel autophagy inhibitor with an adjuvant of chemotherapy against lung cancer. Toxicol Appl Pharmacol 477:116679.
 
  • Zheng N, Gui Z, Liu X, Wu Y, Wang H, Cai A, Wu J, Li X, Kaewborisuth C, Zhang Z, Wang Q, Manyande A, Xu F, Wang J (2023) Investigation of brain-wide functional and structure networks of dopaminergic and CamKIIa-positive neurons in VTA with DREADD-fMRI and neurotropic virus tracing technologies. J Transl Med 21:543.
 
  • Han Z, Luo N, Ma W, Liu X, Cai Y, Kou J, Wang J, Li L, Peng S, Xu Z, Zhang W, Qiu Y, Wu Y, Ye C, Lin K, Xu F (2023) AAV11 enables efficient retrograde targeting of projection neurons and enhances astrocyte-directed transduction. Nat Commun 14:3792.
 
  • Zhu J, Chen C, Li Z, Liu X, He J, Zhao Z, He M, Nie B, Liu Z, Chen Y, Chen K, Xiang H, Xu F, Lin K, Zhang Z, Wang J (2023) Overexpression of Sirt6 ameliorates sleep deprivation induced-cognitive impairment by modulating glutamatergic neuron function. Neural Regen Res 18:1-10.
  • Sun T, Du H, Li Z, Xiong J, Liu Y, Li Y, Zhang W, Liang F, He J, Liu X*, Xiang H (2022) Decoding the contributions of gut microbiota and cerebral metabolism in acute liver injury mice with and without cognitive dysfunction. CNS Neurosci Ther  Suppl 1: 31-42.
 
  • Mu J, Liu X^, Dong Y, Fang Y, Qiu S, Zhang F, Liu K (2022) Peripheral interleukin-6-associated microglial QUIN elevation in basolateral amygdala contributed to cognitive dysfunction in a mouse model of postoperative delirium. Front Med 9:998397.
 
  • Li M, Liu Z, Wu Y, Zheng N, Liu X, …8 authors…, Xu F, Wang J (2022) In vivo imaging of astrocytes in the whole brain with engineered AAVs and diffusion-weighted magnetic resonance imaging. Mol Psychiatry Doi:10.1038/s41380-022-01580-0.
 
  • Sun X, Liu Y, …7 authors…Liu X,…17 authors…, Wu WKK (2022) SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1. Cell Death Differ 29:1240-1254.
  • Zhou J, Sun W, Liu Y, Yang S, Wu S, Wang S, Xiong D, Ho HT, Zhang L, Chan TV, Wu KK, Liu X*, Xiao L* (2021) Clinical characteristics, treatment effectiveness, and predictors of response to pharmacotherapeutic interventions among patients with herpetic-related neuralgia: A retrospective analysis. Pain and therapy 10:1511-1522.
 
  • Ho HT, Ng HL, Cheng X, Gin T, Chan CS, Sun W, Xiao L, Zhang L, Chan TV, Wu KK*, Liu X* (2021) Annexin A2 traps mu-opioid receptors in recycling endosomes upon remifentanil-induced internalization. Neurobiology of pain 10:100071.
 
  • Huang D, Wang X, Liu Y, Huang Z, Hu X, Hu W, Li Q, Chan H, Zou Y, Ho HT, Wang Y, Cheng SL, Kang W, To KF, Wang HT, Wong H, Yu J, Gin T, Zhang Q, Li Z, Shen J, Zhang L, Chan TV*, Liu X*, Wu KK* (2021) Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance. Brief Bioinform 22:bbab040.
  • Wang K^, Liu X^, Liu Q^, Ho IHT, …8 authors…, Zhang L, Chan MTV, Wu WKK, Du B and Xiao J (2020) Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells. Cell Death Dis 11:611.
 
  • Ho IHT, Chan MTV, Wu WKK*, Liu X* (2020) Spinal microglia-neuron interactions in chronic pain. J Leukoc Biol 108:1575-1592.
 
  • Wang K Zhan Y, …5 authors…, Liu X, Du B, Wei X and Xiao J (2020) Tubeimoside I-induced lung cancer cell death and they underlying crosstalk between lysosomes and mitochondria. Cell Death Dis Accepted.
 
  • Wang K^, Liu X^, Liu Q^, Ho IHT, …8 authors…, Zhang L, Chan MTV, Wu WKK, Du B and Xiao J (2020) Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells. Cell Death Dis Accepted.
 
  • Ho IHT, Chan MTV, Wu WKK*, Liu X* (2020) Spinal microglia-neuron interactions in chronic pain. J Leukoc Biol Online ahead of print.
 
  • Yuan Q, Liu X, Xian Y, Yao M, Zhang X, Huang P, Wu W, Lin Z (2020) Satellite glia activation in dorsal root ganglion contributes to mechanical allodynia after selective motor fiber injury in adult rats. Biomed Pharmacother 127:110187.
 
  • Ho J^, Chan H^, Liang Y^, Liu X^, Zhang L^, …17 authors…Wu WKK (2020) Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. Crit Care 24:47.
 
  • Wang K, Gong Q, Zhan Y, Chen B, Yin T, Lu Y, Zhang Y, Wang H, Ke J, Du B, Liu X*, Xiao J* (2020) Blockage of autophagic flux and induction of mitochondria fragmentation by paroxetine hydrochloride in lung cancer cells promotes apoptosis via the ROS-MAPK pathway. Front Cell Dev Biol 7:397.
  • Zhang X^, Liu X^, Xian Y, Zhang F, Huang P, Tang Y, Yuan Q, Lin Z (2019) Berberine enhances survival and axonal regeneration of motoneurons following spinal root avulsion and re-implantation in rats. Free Radic Biol Med 143:454-470.
 
  • Yuan Q, Liu X, Xian YF, Tang Y, Zou J, Zhang X, Huang P, Wu W, Song YQ, Lin ZX (2019) Origins of beta amyloid differ between vascular amyloid deposition and parenchymal amyloid plaques in the spinal cord of a mouse model of Alzheimer’s disease. Mol Neurobiol 57:278-289.
 
  • Choi CKK, Chiu YTE, Zhuo X, Liu Y, Pak CY, Liu X, Tse YS, Wang J, Choi CHJ (2019) Dopamine-mediated assembly of citrate-capped plasmonic nanoparticles into stable core-shell nanoworms for intracellular applications. ACS Nano 13(5):5864-5884.
 
  • Xiang X, Wang S, Shao F, Fang J, Xu Y, Wang W, Sun H, Liu X, Du J, Fang J (2019) Electroacupuncture stimulation alleviates CFA-induced inflammatory pain via suppressing P2X3 expression. Int J Mol Sci 20(13). pii:E3248.
 
  • Wang K, Chen B, Yin T, Zhan Y, Lu Y, Zhang Y, Chen J, Wu W, Zhou S, Mao W, Tan Y, Du B, Liu X, Ho HI, Xiao J (2019) N-Methylparoxetine blocked autophagic flux and induced apoptosis by activating ROS-MAPK pathway in non-small cell lung cancer cells. Int J Mol Sci 20(14). pii:E3415.
 
  • Li Z, Ho IHT, Li X, Xu D, Wu WKK, Chan MTV, Li S, Liu X (2019) Long non-coding RNAs in the spinal cord injury: Novel spotlight. J Cell Mol Med 23(8):4883-4890.
 
  • Wang K^, Xiao J^, Liu X^, Jiang Z, Zhan Y, Yin T, He L, Zhang F, Xing S, Chen B, Li Y, Zhang F, Kuang Z, Du B, Gu J (2019) AICD: an integrated anti-inflammatory compounds database for drug discovery. Sci Rep 9(1):7737.
 
  • Ho IHT^, Liu X^, Zou Y^, Liu T, Hu W, Chan H, Tian Y, Zhang Y, Li Q, Kou S, Chan CS, Gin T, Cheng C, Wong SH, Yu J, Zhang L, Wu WKK, Chan MTV (2019) A novel peptide interfering with proBDNF-sortilin interaction alleviates chronic inflammatory pain. Theranostics 9:1651-1665.
 
  • Chen X, Chan H, Zhang L, Liu X, Ho IHT, Zhang X, Ho J, Hu W, Tian Y, Kou S, Chan CS, Yu J, Wong SH, Gin T, Chan MTV*, Sun X*, Wu WKK* (2019) The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux. J Cell Mol Med 23(6):4290-4300.
 
  • Hu W, Zhang L, Li M, Shen J, Liu X, Xiao Z, Wu DL, Ho IHT, Wu JCY, Cheung CKY, Zhang YC, Lau AHY, Ashktorab H, Smoot DT, Fang EF, Chan MTV, Gin T, Gong W, Wu WKK, Cho CH (2019) Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through PDIA3 receptor in gastric epithelial cells. Autophagy 15(4):707-725.
 
  • Li Z, Li X, Chen X, Li S, Ho IHT, Liu X, Chan MTV, Wu WKK (2019) Emerging roles of long non-coding RNAs in neuropathic pain. Cell Prolif 52(1):e12528.
  • Zhan Y, Wang K, Li Q, Zou Y, Chen B, Gong Q, Ho IHT, Yin T, Zhang F, Lu Y, Wu W, Zhang Y, Tan Y, Du B*, Liu X* (2018) The novel autophagy inhibitor alpha-hederin promoted paclitaxel cytotoxicity by increasing reactive species accumulation in non-small lung cancer cells. Int J Mol Sci 19(10): 3221.
 
  • Zheng N^, Liu X^, Zhang R, Ho IHT, Chen S, Xu J, Yao H, Wang J, Yue J, Wang X, Qin L (2018) Jingshu Keli attenuates cervical spinal nerve ligation induced allodynia in rats through inhibition of spinal microglia and Stat3 activation. Spine J S1529-9430(18)30633-8.
 
  • Yi H, Wang K, Du B, He L, Ho IHT, Qiu M, Zou Y, Li Q, Zhan Y, Zhao Z*, Liu X* (2018) Aleuritolic acid impaired autophagic flux and induced apoptosis in Hepatocellular carcinoma HepG2 cells. Molecules 23(6):1338.
 
  • Yi H, Wang K, Jin JF, Jin H, Yang L, Zou Y, Du B*, Liu X* (2018) Elevated Adenylyl Cyclase 9 expression is a potential prognostic biomarker for patients with colon cancer. Med Sci Monit 24:19-25.
 
  • Yi H, Wang K, Jin H, Su JF, Zou Y, Li Q, He L, Liu X* (2018) Overexpression of Rho-Associated Coiled-Coil containing protein kinase 2 is correlated with clinical progression and poor prognosis in breast cancer Med Sci Monit 24:4776-4781.
 
  • Tian Y, Liu X, Jia M, Yu H, Lichtner P, Shi Y, Meng Z, Kou S, Ho IHT, Jia B, Cheng BCP, Lam CKM, Tsang S, Wong SH, Yu J, Cheng CHK, Gin T#, Wu WKK#, Chen Z#, Chan MTV#; Persistent Pain After Surgery Study Investigators (2018) Targeted genotyping identifies susceptibility locus in brain-derived neurotrophic factor gene for chronic postsurgical pain. Anesthesiology 128(3):587-597.
 
  • Liu T, Shi Y, Chan MTV, Peng G, Zhang Q, Sun X, Zhu Z, Xie Y, Sham KWY, Li J, Liu X, Ho IHT, Gin T, Lu Z, Wu WKK, Cheng CHK (2018) Developmental protein kinase C hyper-activation results in microcephaly and behavioural abnormalities in zebrafish. Transl Psychiatry 8(1):232.
 
  • Xiao J, Wang X, Wu Y, Zhao Q, Liu X, Zhang G, Zhao Z, Ning Y, Wang K, Tan Y, Du B (2018) Synergistic effect of resveratrol and HSV-TK/GCV therapy on murine hepatoma cells. Cancer Biol Ther (Epub ahead of print).
 
  • Chan H, Zhao S, Zhang L, Ho J, Leung CHH, Wong WT, Tian Y, Liu X, Kwong TNY, Chan RCY, Yu SSB, Wang MHT, Tse G*, Wong SH*, Chan MTV*, Wu WKK* (2018) Clostridium difficile toxin B induces autophagic cell death in colonocytes. J Cell Mol Med 22(4):2469-2477.
  • Chan H, Ho J, Liu X, Zhang L, Wong SH, Chan MTV, Wu WKK (2017) Potential and use of bacterial small RNAs to combat drug resistance: A systematic review. Infect Drug Resist 10:521-32.
 
  • Ho J, Zhang L, Liu X, Wong SH, Lau BWM, Ngai SPC, Chan H, Choi G, Leung CCH, Wong WT, Tsang S, Gin T, Yu J, Chan MTV*, Wu WKK* (2017) Pathological role and diagnostic value of endogenous host defense peptides in adult and neonatal sepsis: a systematic review. Shock 47(6):673-679.
  • Ho J, Chan H, Wong SH*, Wang MHT, Yu J, Xiao Z, Liu X, Choi G, Leung CCH, Wong WT, Li Z, Gin T, Chan MTV*, Wu WKK* (2016) The involvement of regulatory non-coding RNAs in sepsis: a systematic review. Crit Care 20(1):383.
 
  • Ho J, Yu J, Wong SH, Zhang L, Liu X, Wong WT, Leung CCH, Choi G, Wang MHT, Gin T, Chan MTV*, Wu WKK* (2016) Autophagy in sepsis: degradation into exhaustion? Autophagy 12(7):1073-82.
2015
  • Liu X, Tian Y, Meng Z, Chen Y, Ho IHT, Choy KW, Lichtner P, Wong SH, Yu J, Gin T, Wu WKK, Cheng CH, Chan MTV (2015) Up-regulation of cathepsin G in the development of chronic postsurgical pain: an experimental and clinical genetic study. Anesthesiology 123(4):838-850.
  2014
  • Wang C, Wu WKK, Liu X, To K, Chen GG, Yu J, Ng EK (2014) Increased serum chemerin level promotes cellular invasiveness in gastric cancer: a clinical and experimental study. Peptides 51:131-138.
  2013
  • Liu X, Tian Y, Lu N, Gin T, Cheng CH, Chan MTV (2013) Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes. PLoS One 8(10):e75804.
 
  • Dong Y, Zhao J, Wu CW, Zhang L, Liu X, Kang W, Leung WW, Zhang N, Chan FK, Sung JJ, Ng SS, Yu J (2013) Tumor suppressor functions of miR-133a in colorectal cancer. Mol Cancer Res 11(9):1051-1060.
 
  • Chen Y, Liu X, Cheng HKC, Gin T, Leslie K, Myles P, Chan MTV (2013) Leukocyte DNA damage and wound infection after nitrous oxide administration: a randominzed controlled trial. Anesthesiology 118(6):1322-1331.
  Before 2013
  • Zhu L, Bi W, Liu X, Li J, Wu Y, Du B, Tan Y (2011) Induction of apoptosis by evodiamine involves both activation of mitotic arrest and mitotic slippage. Oncol Rep 26(6):1447-1455.
 
  • Zhu L, Liu X, Tan Y, Li J, Du B, Wu Y (2009) Proliferation-inhibited and apoptosis-induced effects of evodiamine on human hepatoma cell line HepG2. Chinese Pharmacological Bulletin 25(1):68-71.
 
  • Guan H, Liu X, Peng W, Cao R, Ma Y, Chen H, Xu A (2006) Beta-carboline derivatives: novel photosensitizers that intercalate into DNA to cause direct DNA damage in photodynamic therapy. Biochem Biophys Res Commun342(3):894-901.
 
  • Guan H, Chen H, Peng W, Ma Y, Cao R, Liu X, Xu A (2006) Design of beta-carboline derivatives as DNA-targeting antitumor agents. Eur J Med Chem 41(10):1167-79.
 
  • Cao R, Peng W, Chen H, Ma Y, Liu X, Hou X, Guan H, Xu A (2005) DNA binding properties of 9-substituted harmine derivatives. Biochem Biophys Res Commun. 338(3):1557-1563.
 
  • Cao R, Chen H, Peng W, Ma Y, Hou X, Guan H, Liu X, Xu A (2005) Design, synthesis and in vitro and in vivo antitumor activities of novel beta-carboline derivatives. Eur J Med Chem. 40(10):991-1001.

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