Faculty of Medicine,
The Chinese University of Hong Kong

Prof. CHEN Huarong

Professor

Prof. CHEN Huarong

PhD

Assistant Professor (Non-clinical)
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

Principal Investigator

State Key Laboratory of Digestive Diseases & Li Ka Shing Institute of Health Sciences
The Chinese University of Hong Kong

My research interests are in RNA modifications, GI cancer and sepsis

Prof. CHEN Huarong

Publications

For details about citations arising from my publications and links to online versions of some of the publications (co-first#; senior author*), refer to:
https://www.webofscience.com/wos/author/record/ABH-8561-2020
https://www.researchgate.net/profile/Huarong_Chen


  • Su H, Cheung H, Lau HC, Chen H, Zhang X, Qin N, Wang Y, Chan MTV, Wu WKK, CHEN Huarong*. Crosstalk between gut microbiota and RNA N6-methyladenosine modification in cancer. FEMS Microbiol Rev. 2023 Jul 5;47(4):fuad036.
 
  • Wang Y, CHEN Huarong*. Protein Glycosylation Alterations in Hepatocellular Carcinoma: Function and Clinical Implications. Oncogene. 2023 Jun; 42(24):1970-1979.
 
  • Chen H, Zhang X, Su H, Zeng J, Chan H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV*, CHEN Huarong*. Immune dysregulation and RNA N6-methyladenosine modification in sepsis. Wiley Interdiscip Rev RNA. 2023 May-Jun;14(3):e1764.
 
  • Li Q, Chan H, Liu WX, Liu CA, Zhou Y, Huang D, Wang X, Li X, Xie C, Liu WY, Wang XS, Ng SK, Gou H, Zhao LY, Fong W, Jiang L, Lin Y, Zhao G, Bai F, Liu X, CHEN Huarong, Zhang L, Wong SH, Chan MTV, Wu WKK, Yu J. Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice. Cancer Cell. 2023 Aug 14;41(8):1450-1465.e8.
 
  • Pan Y, CHEN Huarong, Zhang X, Liu W, Ding Y, Huang D, Zhai J, Wei W, Wen J, Chen D, Zhou Y, Liang C, Wong N, Man K, Cheung AH, Wong CC, Yu J. METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy. Cell Rep Med. 2023 Aug 15;4(8):101144.
 
  • Zhou Q, Peng Y, Ji F, CHEN Huarong, Kang W, Chan LS, Gou H, Lin Y, Huang P, Chen D, Wei Q, Su H, Liang C, Zhang X, Yu J, Wong CC. Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer. Nat Commun. 2023 Aug 4;14(1):4677.
 
  • Zhai J, CHEN Huarong, Wong CC, Peng Y, Gou H, Zhang J, Pan Y, Chen D, Lin Y, Wang S, Kang W, To KF, Chen Z, Nie Y, He HH, Sung JJ, Yu J. ALKBH5 Drives Immune Suppression via targeting AXIN2 to Promote Colorectal Cancer and is a Target for Boosting Immunotherapy. Gastroenterology. 2023 Aug;165(2):445-462.
 
  • Bao Y, Zhai J, CHEN Huarong, Wong CC, Liang C, Ding Y, Huang D, Gou H, Chen D, Pan Y, Kang W, To KF, Yu J. Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer. Gut. 2023 Aug;72(8):1497-1509.
 
  • Wang X, Wong CC, CHEN Huarong, Fu K, Shi L, Su H, Guo S, Gou H, Hu X, Zhang L, Ji J, Yu J. The N6-methyladenine DNA demethylase ALKBH1 promotes gastric carcinogenesis by disrupting NRF1 binding capacity. Cell Reports. 2023 Mar 22;42(3):112279.
 
  • Yang Z, Gao S, Wong CC, Liu W, CHEN Huarong, Shang H, Wu ZY, Xu L, Zhang X, Wong N, Kuang M, Yu J. TUBB4B is a novel therapeutic target in nonalcoholic fatty liver disease-associated hepatocellular carcinoma. J Pathol. 2023 May;260(1):71-83.
  • CHEN Huarong, Pan Y, Zhou Q, Liang C, Wong CC, Zhou Y, Huang D, Liu W, Zhai J, Gou H, Su H, Zhang X, Xu H, Wang Y, Kang W, Wu WKK, Yu J. METTL3 inhibits anti-tumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer. Gastroenterology. 2022 Oct;163(4):891-907.
 
  • Wang Y#, CHEN Huarong#, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W. MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target. 2022 Sep 6;12(15):6509-6526.
 
  • Huang D, Wang X, Huang Z, Liu Y, Liu X, Gin T, Wong SH, Yu J, Zhang L, Chan MTV*, CHEN Huarong*, Wu WKK*. 3′ Untranslated Regions of Tumor Suppressor Genes Evolved Specific Features to Favor Cancer Resistance. Oncogene. 2022 Jun;41(23):3278-3288.
 
  • Zeng J, Xie C, Zhang L, Liu X, Chan MTV, Wu WKK*, CHEN Huarong*. Host cell antimicrobial responses against Helicobacter pylori infection: from biological aspects to therapeutic strategies. Int J Mol Sci. 2022 Sep 19;23(18):10941.
 
  • Wang Y#, CHEN Huarong#, Yu J, Kang W, To KF. Recent insight into the role and therapeutic potential of YAP/TAZ in gastrointestinal cancers. Biochim Biophys Acta Rev Cancer. 2022 Aug 28;1877(5):188787.
 
  • Zhang X, Su H, Chen H, Li Q, Liu X, Zhang L, Wu WKK, Chan MTV*, CHEN Huarong*. RNA modifications in Gastrointestinal Cancer: Current Status and Future Perspectives. Biomedicines. 2022 Aug 8;10(8):1918.
 
  • CHEN Huarong#*, Wang Y#, Su H, Zhang X, Chen H, Yu J*. RNA N6-Methyladenine Modification, Cellular Reprogramming, and Cancer Stemness. Front Cell Dev Biol. 2022 Jul 4;10:935224.
 
  • Qian Y, Zhou L, Luk STY, Xu J, Li W, Gou H, CHEN Huarong, Kang W, Yu J, Wong CC. The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade. Oncogene. 2022 Dec 23;42(8):601–12.
 
  • Wang X, Zhang L, Liang Q, Wong CC, CHEN Huarong, Gou H, Dong Y, Liu W, Li Z, Ji J, Yu J. DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance. Oncogenesis. 2022 Oct 28;11(1):66.
 
  • Chan H, Li Q, Wang X, Liu WY, Hu W, Zeng J, Xie C, Kwong TNY, Ho IHT, Liu X, CHEN Huarong, Yu J, Ko H, Chan RCY, Ip M, Gin T, Cheng ASL, Zhang L, Chan MTV, Wong SH, Wu WKK. Vitamin D 3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification. Autophagy. 2022 Sep;18(9):2050-2067.
 
  • Wong CC, Wu JL, Ji F, Kang W, Bian X, CHEN Huarong, Chan LS, Luk STY, Tong S, Xu J, Zhou Q, Liu D, Su H, Gou H, Cheung AH, To KF, Cai Z, Shay JW, Yu J. The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer. Nat Commun. 2022 Jul 8;13(1):3971.
 
  • Wang X, Cheng FTF, Lam TYT, Liu Y, Huang D, Liu X, CHEN Huarong, Zhang L, Ali Y, Wang MHT, Yu J, Gin T, Chan MTV, Wu WKK, Wong SH. Stress Hyperglycemia Is Associated With an Increased Risk of Subsequent Development of Diabetes Among Bacteremic and Nonbacteremic Patients. Diabetes Care. 2022 Jun 2;45(6):1438-1444.
 
  • Sun X, Liu Y, Huang Z, Xu W, Hu W, Yi L, Liu Z, Chan H, Zeng J, Liu X, CHEN Huarong, Yu J, Chan FKL, Ng SC, Wong SH, Wang MH, Gin T, Joynt GM, Hui DSC, Zou X, Shu Y, Cheng CHK, Fang S, Luo H, Lu J, Chan MTV, Zhang L, Wu WKK. SARS-CoV-2 Non-Structural Protein 6 Triggers NLRP3-dependent Pyroptosis by Targeting ATP6AP1. Cell Death Differ. 2022 Jun;29(6):1240-1254.
 
  • Wang X, Hu W, Li X, Huang D, Li Q, Chan H, Zeng J, Xie C, CHEN Huarong, Liu X, Gin T, Wang MH, Cheng ASL, Kang W, To KF, Plewczynski D, Zhang Q, Chen X, Chan DCW, Ko H, Wong SH, Yu J, Chan MTV, Zhang L, Wu WKK. Single-Hit Inactivation Drove Tumor Suppressor Genes Out of the X Chromosome during Evolution. Cancer Res. 2022 Apr 15;82(8):1482-1491.
 
  • Wang S, Gao S, Zeng Y, Zhu L, Mo Y, Wong CC, Bao Y, Su P, Zhai J, Wang L, Soares F, Xu X, CHEN Huarong, Hezaveh K, Ci X, He A, McGaha T, O’Brien C, Rottapel R, Kang W, Wu J, Zheng G, Cai Z, Yu J, He HH. N6-methyladenosine reader YTHDF1 promotes ARHGEF2 translation and RhoA signaling in colorectal cancer. Gastroenterology. 2022 Apr;162(4):1183-1196.
  • CHEN Huarong, Gao S, Liu W, Wong CC, Wu J, Wu J, Liu D, Gou H, Kang W, Zhai J, Li C, Su H, Wang S, Soares F, Han J, He HH, Yu J. RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target. Gastroenterology. 2021 Mar;160(4):1284-1300.
 
  • CHEN Huarong#, Liu W#, Wang Y, Liu D, Zhao L, Yu J. SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients. EBioMedicine. 2021 Aug;70:103500.
 
  • Zhang J, Zhai J, Wong CC, CHEN Huarong, Wang X, Ji J, Yu J. A novel amplification gene PCI Domain Containing 2 (PCID2) promotes colorectal cancer through directly degrading a tumor suppressor Promyelocytic leukemia (PML). Oncogene. 2021 Dec;40(49):6641-6652
 
  • Gao S, Soares F, Wang S, Wong CC, CHEN Huarong, Yang Z, Liu W, Go MYY, Ahmed M, Zeng Y, O’Brien CA, Sung JJY, He HH, Yu J. CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer. Oncogene. 2021 Dec;40(48):6601-6613.
 
  • Liu D, Wong CC, Zhou Y, Li C, CHEN Huarong, Ji F, Go MYY, Wang F, Su H, Wei H, Cai Z, Wong N, Wong VWS, Yu J. Squalene epoxidase induces nonalcoholic steatohepatitis via binding to carbonic anhydrase and is a therapeutic target. Gastroenterology. 2021 Jun; 160(7):2467-2482.e3.
 
  • Liu W, Zhang X, Xu H, Li S, Lau HC, Chen Q, Zhang B, Zhao L, CHEN Huarong, Sung JJ, Yu J. Microbial community heterogeneity within colorectal neoplasia and its correlation with colorectal carcinogenesis. Gastroenterology. 2021 Jun;160(7):2395-2408.
 
  • Chen Y, Cheng WY, Shi H, Huang S, CHEN Huarong, Liu D, Xu W, Yu J, Wang J. Classifying gastric cancer using FLORA reveals clinically-relevant molecular subtypes and highlights LINC01614 as a biomarker for patient prognosis. Oncogene. 2021 Apr;40(16):2898-2909.
  • Wang Y#, CHEN Huarong#, Zhang J, Cheng ASL, Yu J, To KF, Kang W. MCM family in gastrointestinal cancer and other malignancies: from functional characterization to clinical implication. Biochim Biophys Acta Rev Cancer. 2020 Dec;1874(2):188415.
 
  • Pan Y#, CHEN Huarong#, Yu J. Biomarkers in Hepatocellular Carcinoma: Current Status and Future Perspectives. Biomedicines. 2020 Dec 7;8(12):576.
 
  • CHEN Huarong, Yu J. (2020) Crosstalk of Molecular Signaling in Hepatocellular Carcinoma. In: Radu-Ionita F., Pyrsopoulos N., Jinga M., Tintoiu I., Sun Z., Bontas E. (eds) Liver Diseases. Springer, Cham.
 
  • Wong CC, Xu J, Bian X, Wu JL, Kang W, Qian Y, Li W, CHEN Huarong, Gou H, Liu D, Yat Luk ST, Zhou Q, Ji F, Chan LS, Shirasawa S, Sung JJ, Yu J. In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance. Gastroenterology. 2020 Dec;159(6):2163-2180.e6.
  • CHEN Huarong, Wong CC, Liu D, Go MYY, Wu B, Peng S, Kuang M, Wong N, Yu J. APLN promotes hepatocellular carcinoma through activating PI3K/Akt pathway and is a druggable target. Theranostics. 2019 Jul 9; 9(18):5246-5260.
 
  • Wong CC, Kang W, Xu J, Qian Y, Luk STY, CHEN Huarong, Li W, Zhao L, Zhang X, Chiu PW, Ng EK, Yu J. Prostaglandin E-2 induces DNA hypermethylation in gastric cancer in vitro and in vivo. Theranostics. 2019 Aug 14;9(21):6256-6268.
 
  • Dong Y, Zhang Y, Kang W, Wang G, CHEN Huarong, Higashimori A, Nakatsu G, Go M, Tong JH, Zheng S, To KF, Sung JJ, Yang X, Ng SS, Yu J. VSTM2A Suppresses Colorectal Cancer and Antagonizes Wnt Signaling Receptor LRP6. Theranostics. 2019 Aug 21;9(22):6517-6531.
 
  • Gou H, Liang JQ, Zhang L, CHEN Huarong, Zhang Y, Li R, Wang X, Ji J, Tong JH, To KF, Sung JJ, Chan FK, Fang JY, Yu J. TTPAL promotes colorectal tumorigenesis by stabilizing TRIP6 to activate Wnt/β-catenin signaling. Cancer Res. 2019 Jul 1;79(13):3332-3346.
 
  • Wang X, Liang JQ, Zhang LH, Gou H, Li Z, CHEN Huarong, Dong Y, Ji J, Yu J. C8orf76 promotes gastric tumorigenicity and metastasis by directly inducing lncRNA DUSP5P1 and associates with patient outcomes. Clin Cancer Res. 2019 May 15;25(10):3128-3140.
 
  • Zhang L, Li W, Cao L, Xu J, Qian Y, CHEN Huarong, Zhang Y, Kang W, Gou H, Wong CC, Yu J. PKNOX2 suppresses gastric cancer through the transcriptional activation of IGFBP5 and p53. Oncogene. 2019 Jun;38(23):4590-4604.
  • Tang J*, Huarong Chen*, Wong CC, Liu D, Li T, Wang X, Ji J, Sung JJ, Fang JY, Yu J. DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients. Oncogene. 2018 May;37(22):3006-3021. (IF = 7.971)

  • Liu D, Wong CC, Fu L, Huarong Chen, Zhao L, Li C, Zhou Y, Zhang Y, Xu W, Yang Y, Wu B, Cheng G, Lai PB, Wong N, Sung JJY, Yu J. Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a direct pharmaceutical target. Sci Transl Med. 2018 Apr 18;10(437). (IF = 16.304)

  • Weilin Li, Chi Chun Wong, Xiaoming Zhang, Wei Kang, Geicho Nakatsu, Qinfu Zhao, Huarong Chen, Minnie Yin Yin Go, Philip Wai Yan Chiu, Xiaohong Wang, Jiafu Ji, Xiaona Li, Zongwei Cai, Enders Kwok Wai Ng & Jun Yu. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1a axis to inhibit gastric tumorigenesis. Oncogene. 2018 Dec;37(50):6383-6398. (IF = 7.971)

    • CHEN Huarong, Cai W, Chu ES, Tang J, Wong CC, Wong SH, Sun W, Liang Q, Fang J, Sun Z, Yu J. Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice. Oncogene. 2017 Aug;36(31):4415-4426.
     
    • Qian Y, Wong CC, Xu J, CHEN Huarong, Zhang Y, Kang W, Wang H, Zhang L, Li W, Chu ESH, Go MYY, Chiu PWY, Ng EKW, Chan FKL, Sung JJY, Si J, Yu J. Sodium channel subunit SCNN1B suppresses gastric cancer growth and metastasis via GRP78 degradation. Cancer Res.2017 Apr 15;77(8):1968-1982.
    • CHEN Huarong#, Sun X#, Ge W, Qian Y, Bai R, Zheng S. A Seven-Gene Signature Predicts Overall Survival of Patients with Colorectal Cancer. Oncotarget. 2016 Aug 1;8(56):95054-95065.
     
    • Qian Y, Wong CC, Lai S, CHEN Huarong, He X, Sun L, Wu J, Zhou J, Yu J, Liu W, Zhou D, Si J. A retrospective study of pyogenic liver abscess focusing on Klebsiella pneumoniae as a primary pathogen in China from 1994 to 2015. Sci Rep. 2016 Dec 8; 6: 38587.
     
    • Wong CC, Qian Y, Li X, Xu J, Kang W, Tong JH, To KF, Jin Y, Li W, CHEN Huarong, Go MY, Wu JL, Cheng KW, Ng SS, Sung JJ, Cai Z, Yu J. SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations, and Xenograft Tumor Progression in Mice, via Intracellular Synthesis of Aspartate. Gastroenterology. 2016 Nov;151(5):945-960.
     
    • Bai L, Yu Z, Zhang J, Yuan S, Liao C, Jeyabal PV, Rubio V, CHEN Huarong, Li Y, Shi ZZ. OLA1 contributes to epithelial-mesenchymal transition in lung cancer through the modulation of GSK3β/snail/E-cadherin signaling. Oncotarget. 2016 Mar 1;7(9):10402-13.
    • CHEN Huarong#, Song R#, Wang G#, Ding Z, Yang C, Zhang J, Zeng Z, Rubio V, Wang L, Zu N, Weiskoff AM, Minze LJ, Jeyabal PV, Mansour OC, Bai L, Merrick WC, Zheng S, Shi ZZ. OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation. Sci Rep. 2015 Aug 18; 5:13241.
    • Zhu L#, CHEN Huarong#, Zhou D, Li D, Bai R, Zheng S, Ge W. MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility. Med Oncol. 2012 Jun;29(2):1037-43.
    • Zhou J, Zhang M, Huang Y, Feng L, Chen H, Hu Y, CHEN Huarong, Zhang K, Zheng L, Zheng S. MicroRNA-320b promotes colorectal cancer proliferation and invasion by competing with its homologous microRNA-320a. Cancer Lett. 2015 Jan 28; 356(2 Pt B):669-75.
    • Fu Z, Song P, Li D, Yi C, CHEN Huarong, Ruan S, Shi Z, Xu W, Fu X, Zheng S. Cancer-associated fibroblasts from invasive breast cancer have an attenuated capacity to secrete collagens. Int J Oncol. 2014 Oct; 45(4):1479-88.
    • Jeyabal PV, Rubio V, CHEN Huarong, Zhang J, Shi ZZ. Regulation of cell-matrix adhesion by OLA1, the Obg-like ATPase 1. Biochem Biophys Res Commun. 2014 Feb 21; 444(4):568-74.
    • Mao RF, Rubio V, CHEN Huarong, Bai L, Mansour OC, Shi ZZ. OLA1 protects cells in heat shock by stabilizing HSP70. Cell Death Dis. 2013 Feb 14; 4:e491.
    • Fu Z, Zuo Y, Li D, Xu W, Li D, CHEN Huarong, Zheng S. The crosstalk: Tumor-infiltrating lymphocytes rich in regulatory T cells suppressed cancer-associated fibroblasts. Acta Oncol. 2013 Nov;52(8):1760-70.
    • Hu H, Zhang H, Ge W, Liu X, Loera S, Chu P, CHEN Huarong, Peng J, Zhou L, Yu S, Yuan Y, Zhang S, Lai LL, Yen Y, Zheng S. Secreted Protein Acidic and Rich in Cysteines-Like 1 Suppresses Aggressiveness and Predicts Better Survival in Colorectal Cancers. Clin Cancer Res. 2012 Oct 1;18(19):5438-48.

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