Faculty of Medicine,
The Chinese University of Hong Kong

Prof. ZHANG Lin

Professor

Prof. ZHANG Lin

BM (Hons), PhD

Assistant Professor
Department of Medicine and Therapeutics
The Chinese University of Hong Kong

Assistant Professor (by courtesy)
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

My research interests focus on the early life microbiome basic and translational study with the aim to define disease-causing microbes and their transfer to infants, discover of health-promoting microbes to establish health in children, and innovate personalized and rationally designed microbiota therapeutics that could reshape/manipulate the dysbiotic microbiota to prevent diseases in early childhood.

Prof. ZHANG Lin

Publications

For details about citations arising from my publications and links to online versions of some of the publications, refer to:
http://www.researcherid.com/rid/C-7606-2009 (Researcher ID: O-9109-2015)


  • Zeng JD^ , Xie C^, Huang ZH, Chi Cho C, Chan H, Li Q, Ashktorab H, Smoot D, Wong S, Jun Yu J, Wei Gong W, Liang C, Xu HZ, Chen HR, Liu XD, Wu JT, Ip M, Gin T, Zhang L*, Chan MTV*, Hu W*, Wu WKK* (2024) LOX-1 acts as an N6-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase. Nature Communications, 15(1), 1-17.
 
  • Chan OM^, Xu W^, Cheng NS, Leung ASY, Ching JYL, Fong BLY, Cheong PK, Zhang L, Chan FKL, Ng SC, Leung TF*. (2024). A novel infant microbiome formula (SIM03) improved eczema severity and quality of life in preschool children. Scientific Reports, 14(1), 3168.
  • Peng Y, Zhang L^, Mok CKP, Ching JYL, Zhao SL, Wong MKL, Zhu J, Chen CK, Wang SL, Yan S, Qin BY, Liu YZ, Zhang X, Cheung CP, Cheong PK, Ip LK, Fung ACH, Wong KKY, Hui DSC, Chan FKL, Ng SC, Tun HM. (2023). Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines. Signal Transduction and Targeted Therapy, 8(1), 373.
 
  • Wong MCS, Zhang L^, Ching JYL, Mak JWY, Huang JJ, Wang SL, Mok CKP, Wong A, Chiu OL, Fung YT, Cheong PK, Tun HM, Ng SC, Chan FKL. (2023). Effects of Gut Microbiome Modulation on Reducing Adverse Health Outcomes among Elderly and Diabetes Patients during the COVID-19 Pandemic: A Randomised, Double-Blind, Placebo-Controlled Trial (IMPACT Study). Nutrients. 15(8):1982. doi: 10.3390/nu15081982.
 
  • Li Q, Chan H, Liu WX, Liu CA, Zhou YF, Huang D, Wang XL, Li XX, Xie C, Liu WYZ, Wang XS, Ng SK, Gou HY, Zhao LY, Fong W, Jiang LP, Lin YF, Zhao GJ, Bai FH, Liu XD, Chen HR, Zhang L, Wong SH, Chan MTV, Wu WKK, Yu J (2023). Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice. Cancer Cell, 41(8), 1450-1465.  
 
  • Huang Y, Zhang L, Hu J, Liu H. (2023). Improved Loading Capacity and Viability of Probiotics Encapsulated in Alginate Hydrogel Beads by In Situ Cultivation Method. Foods, 12(11), 2256.
 
  • Zhao HP, Feng AP, Luo D, Wu H, Zhang G, Zhang L, Yuan JQ, Lin YF, Li LH, Zou HC. (2023) Altered gut microbiota is associated with different immunologic responses to antiretroviral therapy in HIV-infected men who have sex with men. Journal of Medical Virology. 95(3):e28674. doi: 10.1002/jmv.28674.
 
  • Chen HY, Zhang XT, Su H, Zeng JD, Chan H, Li Q, Liu XD, Zhang L, Wu WKK, Chan MTV, Chen HR. (2023). Immune dysregulation and RNA N6‐methyladenosine modification in sepsis. Wiley Interdisciplinary Reviews: RNA, 14(3), e1764.
  • Wang X, Hu W, Li X, Huang D, Li Q, Chan H, Zeng J, Xie C, Chen H, Liu X, Gin T, Wang MH, Cheng ASL, Kang W, To KF, Plewczynski D, Zhang Q, Chen X, Chan DCW, Ko H, Wong SH, Yu J, Chan MTV, Zhang L*, Wu WKK. (2022). Single-hit inactivation drove tumor suppressor genes out of the X chromosome during evolution. Cancer Research. 82(8), 1482-1491.
  • Zhang L^, Xu Z, Mak JWY, Chow KM, Lui G, Li TCM, Wong CK, Chan PKS, Ching JYL, Fujiwara Y, Chan FKL, Ng SC. Gut microbiota-derived synbiotic formula (SIM01) as a novel adjuvant therapy for COVID-19: An open-label pilot study. (2022) J Gastroenterol Hepatol. 37(5), 823-831.
  • Ng SC, Peng Y, Zhang L^, Mok CK, Zhao S, Li A, Ching JY, Liu Y, Yan S, Chan DLS, Zhu J, Chen C, Fung AC, Wong KK, Hui DS, Chan FK, Tun HM. Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events (2022) Gut, 71(6), 1106-1116.
  • Sun X, Liu Y, Huang ZH, Xu WY, Hu W, Yi L, Liu Z, Chan H, ZGeng JD, Liu XD, Chen HR, Yu J, Chan FKL, Ng SC, Wong SH, Wang MHT, Gin T, Joynt GM, Hui DSC, Zou X, Shu YL, Cheng CHK, Fang SS, Luo HL, Lu J, Chan MTV, Zhang L*, Wu WKK. (2022) SARS-CoV-2 Non-Structural Protein 6 Triggers NLRP3-dependent Pyroptosis by Targeting ATP6AP1. Cell Death and Differentiation, 29(6), 1240-1254.
  • Su Q, Liu Q, Lau RI, Zhang JW, Xu ZL, Yeoh YK, Leung TWH, Tang W, Zhang L, Liang JQY, Yau YK, Zheng JY, Liu CY, Zhang MJ, Cheung CP, Ching JYL, Tun HM, Yu J, Chan FKL, Ng SC. (2022) Faecal microbiome-based machine learning for multi-class disease diagnosis. Nature Communications, 13(1), 6818.
  • Huang D, Wang XS, Huang ZH, Liu YZ, Liu XD, Gin T, Wong SH, Yu J, Zhang L, Chan MTV, Chen, Wu WKK. (2022). 3′ untranslated regions of tumor suppressor genes evolved specific features to favor cancer resistance. Oncogene, 41(23), 3278-3288.
  • Su Q, Liu Q, Zhang L, Xu ZL, Liu CY, Lu WQ, Ching JYL, Li A, Mak JWY, Lui GCY, Ng SSS, Chow KM, Hui DSC, Chan PKS, Chan FKL, Ng SC. (2022) Antibiotics and probiotics impact gut antimicrobial resistance gene reservoir in COVID-19 patients. Gut Microbes, 14(1), 2128603.
  • Zhang F, Wan MT, Zuo T, Yeoh YK, Liu Q, Zhang L, Zhan H, Lu WQ, Xu WY, Lui GCY, Li AYL, Cheung CP, Wong CK, Chan PKS, Chan FKL, Ng SC. (2022) Prolonged Impairment of Short-Chain Fatty Acid and L-Isoleucine Biosynthesis in Gut Microbiome in Patients With COVID-19. Gastroenterology, 162(2), 548-561.
  • Pedersen SS, Holse C, Mathar CE, Chan MTV, Sessler DI, Liu YZ, Zhang L, Kurz A, Jacka M, Torborg A, Biyase T, Montes FR, Wang CY, Pettit S, Devereaux PJ, Meyhoff CS. (2022) Intraoperative Inspiratory Oxygen Fraction and Myocardial Injury After Noncardiac Surgery: Results From an International Observational Study in Relation to Recent Controlled Trials. Anesthesia & Analgesia. 135(5), 1021-1030.
  • Wang X, Cheng FTF, Lam TYT, Liu Y, Huang D, Liu X, Chen H, Zhang L, Ali Y, Wang MHT, Yu J, Gin T, Chan MTV, Wu WKK, Wong SH. (2022) Stress hyperglycemia is associated with an increased risk of subsequent development of diabetes among bacteremic and nonbacteremic patients. Diabetes Care, 45(6), 1438-1444.
  • Chan H, Li Q, Wang X, Liu WY, Hu W, Zeng J, Xie C, Kwong TNY, Ho IHT, Liu X, Chen H, Yu J, Ko H, Chan RCY, Ip M, Gin T, Cheng ASL, Zhang L, Chan MTV, Wong SH, Wu WKK. Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification. (2022) Autophagy, 18(9), 2050-2067.
  • Sun X, Yu J, Wong SH, Chan MTV, Zhang L*, Wu WKK. (2022) SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell death. Autophagy, 18(9), 2246-2248.
  • Xu WY, Liu Y, Xuan Zou, HL Luo, Wu W, JJ Xia, Chan MTV, Fang S, YL Shu, Wu WKK, Zhang L*(2021) Hypozincemia in COVID-19 patients correlates with stronger antibody response. Frontiers in Immunology, 12, 785599.
 
  • Fang S, Zhang L^, Liu Y, Xu W, Wu W, Huang Z, Wang X, Liu H, Sun Y, Zhang R, Peng B, Liu X, Sun X, Yu J, Chan FKL, Ng SC, Wong SH, Wang MHT, Gin T, Joynt GM, Hui DSC, Feng T, Wu WKK, Chan MTV, Zou X, Xia J(2021) Lysosome activation in peripheral blood mononuclear cells and prognostic significance of circulating LC3B in COVID-19. Brief Bioinform 22(2):1466-1475.
 
  • Liu Y, Ling L, Wong SH, Wang MHT, Fitzgerald J Ross, Zou X, Fang S, Liu X, Wang X, Hu W, Chan H, Wang Y, Huang D, Li Q, Wong WT, Choi G, Zou H, Hui DSC, Yu J, Tse G, Gin T, Wu WKK, Chan MTV, Zhang L* (2021) Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients. EClinicalMedicine, 37.
 
  • Cao L, Zhao S, Li Q, Ling L, Wu WKK, Zhang L, Lou J, Chong MKC, Chen Z, Wong ELY, Zee BCY, Chan MTV, Chan PKS, Wang MH. A Bayesian method for synthesizing multiple diagnostic outcomes of COVID-19 tests. (2021) R Soc Open Sci, 8(9), 201867.
 
  • Zhou J, Sun W, Liu Y, Yang S, Wu S, Wang S, Xiong D, Ho IH, Zhang L, Chan MTV, Wu WKK, Liu X, Xiao L. (2021)  Clinical Characteristics, Treatment Effectiveness, and Predictors of Response to Pharmacotherapeutic Interventions Among Patients with Herpetic-Related Neuralgia: A Retrospective Analysis. Pain and Therapy, 10, 1511-1522.
 
  • Li Q, Hu W, Liu WX, Zhao LY, Huang D, Liu XD, Chan H, Zhang Y, Zeng JD, Coker OO, Kang W, Ng SSM, Zhang L, Wong SH, Gin T, Chan MTV, Wu JL, Yu J, Wu WKK (2021) Streptococcus themophilus inhibits colorectal tumorigenesis through secreting beta galactosidase. Gastroenterology 160(4):1179-1193.e14. [Cover Story]
 
  • Wang X, Liu Y, Huang Z, Hu X, Hu W, Li Q, Chan H, Zou Y, Ho IHT, Wang Y, Cheng ASL, Kang W, To KF, Wang MHT, Wong SH, Yu J, Gin T, Zhang Q, Li Z, Shen J, Zhang L, Chan MTV, Liu X, Wu WKK (2021) Multi-omic analysis suggests tumor suppressor genes evolved specific promoter features to optimize cancer resistance. Briefings in Bioinformatics, 22(5), bbab040.
 
  • Li Z, Li X, Shen J, Tan H, Rong T, Lin Y, Feng E, Chen Z, Jiao Y, Liu G, Zhang L, Chan MTV, Wu WKK (2021) Bioinformatic analysis of SMN1-ACE/ACE2 interactions hinted at a potential protective effect of spinal muscular atrophy against COVID-19-induced lung injury. Brief Bioinform 22(2):1291-1296.  
 
  • Li Z, Huang Z, Li X, Huang C, Shen J, Li S, Zhang L, Wong SH, Chan MTV, Wu WKK (2021) Bioinformatic analyses hinted at augmented T helper 17 cell differentiation and cytokine response as the central mechanism of COVID-19-associated Guillain-Barré syndrome. Cell Prolif , 54(5), e13024.
 
  •  Klionsky DJ, …, Zhang L, et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17(1):1-382.
 
  • Ng YL, Lo CK, Lee KH, Xie X, Kwong TNY, Ip M, Zhang L, Yu J, Sung JJY, Wu WKK, Wong SH, Kwok KW (2021) Development of an open-access and explainable machine learning prediction system to assess the mortality and recurrence risk factors of Clostridioides difficile infection patients. Adv Intell Syst 3(1):2000188.
 
  • Zhang L, Zhan H, Xu WY, Yan S, Ng SC. (2021) The role of gut mycobiome in health and diseases. Therapeutic Advances in Gastroenterology, 14,17562848211047130.
 
  • Li Z, Li X, Xu D, Chen X, Li S, Zhang L, Chan MTV, Wu WKK (2021) An update on the roles of circular RNAs in osteosarcoma. Cell Prolif 54(1): e12936.
  • Ho J, Chan H, Liang Y, Liu X, Zhang L, Li Q, Zhang Y, Zeng J, Ugwu FN, Ho IHT, Hu W, Yau JCW, Wong SH, Wong WT, Ling L, Cho CH, Gallo RL, Gin T, Tse G, Yu J, Chan MTV, Leung CCH, Wu WKK. (2020). Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. Crit Care, 24, 1-16.
 
  • Li Q, Hu W, Liu WX, Zhao LY, Huang D, Liu XD, Chan H, Zhang Y, Zeng JD, Coker OO, Kang W, Ng SSM, Zhang L, Wong SH, Gin T, Chan MTV, Wu JL, Yu J, Wu WKK (2020) Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting beta-galactosidase. Gastroenterology, 160(4), 1179-1193.
 
  • Liu YZ, Chu R, Lee A, Gomersall CD, Zhang L, Gin T, Chan MTV, Wu WKK, Ling L. (2020). A surveillance method to identify patients with sepsis from electronic health records in Hong Kong: a single centre retrospective study. BMC infectious diseases, 20(1), 1-9.
 
  • Kong KY, Kwong TNY, Chan H, Wong K, Wong SSY, Chaparala AP, Chan RCY, Zhang L, Sung JJY, Yu J, Hawkey PM, Ip M, Wu WKK, Wong SH (2020) Biological characteristics associated with virulence in Clostridioides difficile ribotype 002 in Hong Kong. Emerging Microbes & Infections, 9(1), 631-638.
 
  • Li CKH, Xu Z, Ho J, Lakhani I, Liu Y, Bazoukis G, Liu T, Wong WT, Cheng SH, Chan MTV, Zhang L, Gin T, Wong MCS, Wong I, Wu WKK, Zhang Q, Tse G (2020) Association of NPAC score with survival after acute myocardial infarction. Atherosclerosis 301, 30-36.
 
  • Hu JL, Zhang L, Lin W, Tang W, Chan FKL, Ng SC. (2020). Probiotics, prebiotics and dietary approaches during COVID-19 pandemic. Trends in Food Science & Technology, 108, 187-196.
 
  • Li Z, Li X, Shen J, Zhang L, Chan MTV, Wu WKK. (2020). Emerging roles of non-coding RNAs in scoliosis. Cell Prolif, 53(2): e12736.
 
  • Yu X, Wang M, Li L, Zhang L, Chan MTV, Wu WKK (2020) MicroRNAs in atopic dermatitis: a systematic review. J Cell Mol Med 24(11), 5966-5972.
 
  • Fu LW, Wang BY, Yuan TW, Chen XT, Ao YL, Fitzpatrick T, Li PY, Zhou YG, Lin QB, Luo GF, Fan S, Lu Y, Feng AP, Zhan YW, Liang BW, Cai WP, Zhang L, Du XJ, Li LH, Shu YL, Zou HC (2020) Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis. Journal of Infection 80(6), 656-665.
 
  • Wang K, Liu X, Liu Q, Ho IHT, Wei X, Yin T, Zhan Y, Zhang W, Zhang W, Chen B, Gu J, Tan Y, Zhang L, Chan MTV, Wu WKK, Du B, Xiao J (2020) Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells. Cell Death Dis, 11(8), 611.
 
  • Hu W, Zhang L, Wu WKK, Cho CH (2020) Involvement of autophagy in antibacterial actions of vitamin D in Helicobacter pylori infection: abridged secondary publication. Hong Kong Med J, 26(3 Supplement 4).
  • Chen X, Chan H, Zhang L^, Liu X, Ho IHT, Zhang X, Ho J, Hu W, Tian Y, Kou S, Chan CS, Yu J, Wong SH, Gin T, Chan MTV*, Sun X*, Wu WKK*. (2019). The phytochemical polydatin ameliorates non-alcoholic steatohepatitis by restoring lysosomal function and autophagic flux. J Cell Mol Med, 23(6), 4290-4300.
 
  • Sun X, Ng TH, Sham KWY, Zhang L, Chan MTV, Wu WKK, Chen CHK (2019). Bufalin, a traditional Chinese medicine compound, prevents tumour formation in two murine models of colorectal cancer.Cancer Prevention Research, 12(10), 653-666.
 
  • Hu W, Zhang L^, Li MX, Shen J, Liu XD,  Xiao ZG,  Wu DL,  Ho IHT, Wu JCY,  Cheung CKY,  Zhang YC, Lau AHY,  Ashktorab H, Smoot DT,  Fang EF, Chan MTV,  Gin T,* Gong W,* Wu WKK,* Cho CH*. (2019)   Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells. Autophagy 15(4):707-725.
 
  • Ng TH, Sham KWY, Xie CM, Ng SSM, To KF, Tong FHM Liu WYZ, Zhang L, Chan MTV, Wu WKK, Cheng CHK (2019). Eukaryotic elongation factor-2 kinases expression is an independent prognostic factor in colorectal cancer. BMC cancer, 19(1), 649.
 
  • Ho IHT, Liu X, Zou Y, Liu T, Hu W, Chan H, Tian Y, Zhang Y, Li Q, Kou S, Chan CS, Gin T, Cheng C, Wong SH, Yu J, Zhang L, Wu WKK*, Chan MTV (2019) A novel peptide interfering with proBDNF-sortilin interaction alleviates chronic inflammatory pain. Theranostics 9(6):1651-1665.
 
  • Zhang Y, Zhang L, Yang L, Vong CI, Chan KF, Wu WKK, Kwong TNY, Lo NWS, Ip M, Wong SH, Sung JJY, Chiu PWY, Zhang L. (2019). Real-time tracking of fluorescent magnetic spore-based microrobots for remote detection of C. diff toxins. Sci Adv 5(1): eaau9650.
 
  • Hu W, Chan H, Lu L, Wong KT, Wong SH, Li MX, Xiao ZG, Cho CH, Gin T, Chan MTV, Wu WKK, Zhang L. (2019). Autophagy in intracellular bacterial infection. Seminars in Cell and Developmental Biology. (Vol. 101, pp. 41-50). Academic Press
 
  • Ho J, Li XC, Zhang L^, Liang YH, Wong SH, Hu W, Yau JCW, Chan H, Chan MTV, Gin T, Tse G, Wu WKK. (2019) Translational genomics in pancreatic ductal adenocarcinoma: A review with re-analysis of TCGA dataset. Semin Cancer Biol pii: S1044-579X (17)30231-6.
  • Wang X, Li X, Zhang L, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T, Chan MTV, Wu WKK. (2018) Oncogenes expand during evolution to withstand somatic amplification. Annnals of Oncology. 29 (11):2254-2260.
 
  • Zhang L, Hu W, Cho CH, Chan FKL, Yu J, Fitzgerald RJ, Cheung CKY, Xiao ZG, Jing Shen J, Li LF, Li MX, Wu JCY, Ling TKW, Chan JYK, Ho K, Tse G, Ng SC, Yu S, Wang MHT, Gin T, Ashktorab H, Duane T. Smoot DT, Wong SH*, Chan MTV*, Wu WKK*. (2018) Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori. J Pathol 244(4):432-444.
 
  • Zhang L, Zhang YC, Wong SH, Law PTY, Zhao CS, Yu J, Chan MTV, Wu WKK. (2018) Common deregulation of seven biological processes by microRNAs in gastrointestinal cancers.  Sci Rep 10.1038/s41598-018-21573-w.
 
  • Chan H, Zhao S, Zhang L, Ho J, Leung CHH, Wong WT, Tian Y, Liu X, Kwong TNY, Chan RCY, Yu SSB, Wang MHT, Tse G, Wong SH, Chan MTV, Wu WKK. (2018). Clostridium difficile toxin B induces autophagic cell death in colonocytes. J Cell Mol Med, 22(4), 2469-2477.
 
  • Li DZ, Zhou YX, Yu HF, Yu J, Xia YQ, Zhang L, Wu WKK, Zhou YW, Xu SY, Zeng Z, Yao R, Cao Y. (2018) Evaluation of a novel prognostic score based on thrombosis and inflammation in patients with sepsis: a retrospective cohort study. Clin Chem Lab Med 56(7):1182-1192.
 
  • Yu X, Zheng H, Tse G, Zhang L, Wu WKK (2018) CASC2: an emerging tumor-suppressing long non-coding RNA in human cancers and melanoma. Cell Prolif, 51(6): e12506.
 
  • Shen J, Xiao ZG, Zhao QJ, Li MX, Wu X, Zhang L, Hu W, Cho CH (2018). Anti-cancer therapy with TNFα and INF-γ: A comprehensive review. Cell Proliferation DOI:10:111/cpr.12441.
 
  • Xiao ZG, Shen J, Zhang L, Li MX, Hu W, Cho CH (2018). Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects. Oncology Letters 15:3395-3402.
 
  • Shen J, Xiao ZG, Zhao QJ, Li MX, Wu X, Zhang L, Hu W, Cho CH (2018). Anti-cancer therapy with TNFα and INF-γ: A comprehensive review. Cell Proliferation DOI:10:111/cpr.12441.
 
  • Zhang L, Hu W, Ho J, Fitzgerald RJ, Gin T, Chan MTV, Wu WKK*. (2018) Antimicrobial peptides in the host-microbiota homeostasis. In: Antimicrobial Peptides in Gastrointestinal Diseases pp.21-33. Academic Press.
 
  • Wu WKK, Zhang L, Chan MTV, Yu J (2018) Autophagy, NAFLD and NAFLD-related HCC. In: Obesity, Fatty Liver and Liver Cancer, 127-138..
 
  • Shen J, Xiao ZG, Zhao QJ, Li MG, Wu X, Zhang L, Hu W, Cho CH. (2018). Anti‐cancer therapy with TNF α and IFN γ: A comprehensive review. Cell proliferation, 51(4), e12441.
  • Wong CMC, Zhang L, Wu WKK, Shen J, Chan RLY, Lu L, Hu W, Li MX, Li LF, Ren SX, Li YF, Li J, Cho CH. (2017) Cathelicidin-Encoding Lactococcus lactis Promotes Mucosal Repair in Murine Experimental Colitis. J Gastroen Hepatol 32(3):609-619.
 
  • Ho J, Dai RZW, Kwong T, Wang XS, Zhang L, Ip M, Chan RCY, Hawkey PM, Lam Y, Wong M, Tse G, Chan MTV, Chan FKL, Yu J, Ng SC, Lee N, Wu JC, Sung JJY, Wu WKK, Wong SH (2017). Disease burden of Clostridium difficile infections in adults, Hong Kong, China, 2006–2014. Emerg Infect Dis 23(10):1671-79.
 
  • Wong SH, Kwong TNY, Chow TC, Luk AKC, Dai RZW, Nakatsu G, Zhang L, Lam, TYT, Wu JCY, Chan FKL, Ng SSM, Wong MCS, Ng SC, Wu WKK, Yu J, Sung JJY (2017). Quantitation of faecal Fusobacterium improves performance of faecal immunochemical test in detecting advanced colorectal neoplasia. Gut; 66(8):1441-1448.
 
  • Ho J, Zhang L, Liu X, Wong SH, Lau BWM, Ngai SPC, Chan H, Choi G, Leung CCH, Wong WT, Tsang S, Gin T, Yu J, Chan MTV, Wu WKK (2017) Pathological role and diagnostic value of endogenous host defense peptides in adult and neonatal sepsis: a systematic review. Shock 47(6):673-679.
 
  • Li MX, Li LF, Zhang L, Xiao ZG, Shen J, Hu W, Zeng Q, Cho CH (2017). Vitamin D and cancer stem cells in the Gastrointestinal Tract. Current Medicinal Chemistry, 24(9), 918-927.
 
  • Ho J, He W, Chan MTV, Tse G, Liu T, Wong SH, Leung CCH, Wong WT, Tsang S, Zhang L, Chan RYP, Gin T, Leung J, Lau BWM, Wu WKK, Ngai SPC (2017) Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis. Sci Rep 7(1):13451.
 
  • Chan H, Ho J, Liu X, Zhang L, Wong SH, Chan MTV, Wu WKK (2017) Potential and use of bacterial small RNAs to combat drug resistance: A systematic review. Infection and drug resistance, 10, 521.
 
  • Li MX, Li LF, Zhang L, Hu W, Shen J, Xiao ZG, Wu X, Chan FL, Cho CH. (2017). 1, 25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR-and mutant p53-mediated induction of p21. Life Sciences, 179, 88-97.
  • Zhang L, Wu WKK, Gallo RL, Fang EF, Ling TKW, Shen J, Chan RLY, Lu L, Luo XM, Li MX, Chan KM, Yu J, Wong VWS, Ng SC, Wong SH, Chan FKL, Sung JJY, Chan MTV, Wu WKK, Cho CH. (2016). Critical Role of Antimicrobial Peptide Cathelicidin for Controlling Helicobacter pylori Survival and Infection. The Journal of Immunology, 196(4), 1799-1809.
 
  • Shen J, Li ZJ, Lu L, Xiao ZG, Wu WK, Zhang L, Li MX, Hu W, Chan KM, Cho CH. (2016). Vascular-targeted TNFα and IFNγ inhibits orthotopic colorectal tumor growth. J Transl Med. 14(1), 1-13..
 
  • Wang L, Hu T, Shen J, Zhang L, Li LF, Chan RL, Li MX, Wu WKK, Cho CH. (2016). Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells. Life Sci, 151, 224-234.
 
  • Ho J, Yu J, Wong SH, Zhang L, Liu X, Wong WT, Leung CCH, Choi G, Wang MH, Gin T, Chan MTV, Wu WKK (2016). Autophagy in sepsis: Degradation into exhaustion? Autophagy 2;12(7):1073-1082.
 
  • Xiao ZG, Shen J, Zhang L, Li LF, Li MX, Hu W, Li ZJ, Cho CH (2016). The roles of histone demethylase UTX and JMJD3 (KDM6B) in cancers: Current progress and future perspectives. Curr Med Chem 23(32):3687-3696.
 
  • Shen J, Li WX, Xiao ZG, Zhang L, Li MX, Li LF, Hu W, Lu L, Boudreau F, Cho CH (2016). The Co-regulatory role of 5-Lipoxygenase and Cyclooxygenase-2 in the carcinogenesis and their promotion by Cigarette Smokeing in Colons. Curr Med Chem 23(11):1131-8.
2015
  • Cho CH, Yu J, Zhang L, Wu WKK. (2015). The role of cathelicidin in control of Helicobacter pylori colonization in the stomach. Hong Kong Med J 21 Suppl 4:17-19.
  • Shen J, Xiao Z, Wu WKK, Wang MH, To KF, Chen Y, Yang W, Li MSM, Shin VY, Tong JH, Zhang L, Li M, Wang L, Lu L, Chan RLY, Wong SH, Yu J, Chan MTV, Chan FKL, Sung JJY, Cheng ASL, Cho CH (2015) Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis. Cancer Res 75(4): 754-65.
  • Lu L, Li ZJ, Li LF, Wu WKK, Shen J, Zhang L, Chan RLY, Yu L, Liu YW, Ren SX, Chan KM, Cho CH. (2015). Vascular-targeted TNFa improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer. J Control Release 210, 134-146.
  • Ko CH, Chan RLY, Siu WS, Shumn WRT, Leung PC, Zhang L, Cho CH. (2015). Deteriorating effect on bone metabolism and microstructure by passive cigarette smoking through dual actions on osteoblast and osteoclast. Calcified Tissue Int 96, 389-400.
2014
  • Hu T, To KK, Wang L, Zhang L, Lu L, Shen J, Chan RL, Li M, Yeung JH, Cho CH (2014). Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza. Phytomedicine 25;21(11):1264-72.
  • Zhang L, Sung JJY, Yu J, Ng SC, Wong SH, Cho CH, Chan FKL, Wu WKK (2014). Xenophagy in Helicobacter pylori– and Epstein-Barr virus-induced gastric cancer. J Pathol 233(2):103-12.
  • Li LF, Chan RLY, Lu L, Shen J, Zhang L, Wu WKK, Wang L, Hu T, Li MX, Cho CH (2014) Cigarette smoking and gastrointestinal diseases: The causal relationship and underlying molecular mechanisms. Int J Mol Med 34(2):372-80.
  • Wu WKK, Sung JJY, Cheng ASL, Chan FKL, Ng SS, To KF, Wang XJ, Zhang L, Wong SH, Yu J, Cho CH (2014). The Janus faces of cathelicidin in tumorigenesis. Curr Med Chem 21(21):2392-400.
2013
  • Zhang L, Yu J, Wong CCM, Ling TKW, Li ZJ, Chan KM, Ren SX, Shen J, Chan RLY, Lee CC, Li MSM, Cheng ASL, To KF, Gallo RL, Sung JJY, Wu WKK, Cho CH (2013). Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice. Gene Ther 20:751-760.
  • Ren SX, Shen J, Cheng ASL, Lu L, Chan RLY, Li ZJ, Wang XJ, Wong CCM, Zhang L, Ng SSM, Chan FL, Chan FKL, Yu J, Sung JJY, Wu WKK, Cho CH (2013) FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells. PLoS One 8: e63641.
  • Wang L, Yeung JH, Hu T, Lee WY, Lu L, Zhang L, Shen J, Chan RL, Wu WKK, Cho CH (2013) Dihydrotanshinone induces p53 independent but ROS dependent apoptosis in colon cancer cells. Life Sci 93(8):344-51.
  • Shen J, Wu WKK, Ren SX, Zhang L, Chan RL, Wong CC, Lu L, Cho CH (2013) miRNAs in Gastrointestinal and Liver Cancers: Their Perspectives and Clinical Applications. Curr Pharm Des 19(7):1301-10.
2012
  • Zhang L, Ren JW, Wong CCM, Wu WKK, Ren SX, Shen J, Chan RLY, Cho CH (2012). Effects of cigarette smoke and its active components on ulcer formation and healing in the gastrointestinal mucosa. Current Med Chem 19:63-69.
  • Ren SX, Cheng ASL, To KF, Tong JHM, Li MS, Shen J, Wong CCM, Zhang L, Chan RLY, Wang XJ, Ng SSM, Chiu LCM, Marquez VE, Gallo RL, Chan FKL, Yu J, Sung JJY,Wu WKK,Cho CH (2012). Host Immune Defense Peptide LL-37 Activates Caspase-Independent Apoptosis and Suppresses Colon Cancer. Cancer Res 72(24); 1-12.
  • Wong CCM, Zhang L, Li ZJ, Wu WKK, Ren SX, Chen YC, Ng TB, Cho CH (2012). Protective Effects of Cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis. J Gastroen Hepatol. 27(7):1205-1212.
  • Fang EF, Zhang CZY, Zhang L, Fong WP, Ng TB (2012). In vitro and in vivo anticarcinogenic effects of RNase MC2, a ribonuclease isolated from dietary bitter gourd, toward human liver cancer cells. Int J Biochem Cell Biol.44(8):1351-1360.
  • Fang EF, Zhang CZY, Zhang L, Wong JH, Chan YS, Pan WL, Dan XL, Yin CM, Cho CH, Ng TB (2012).Trichosanthin inhibits breast cancer cell proliferation in both cell Lines and nude mice by promotion of apoptosis. PLoS One 7(9): e41592.
  • Zhang L, Cho CH (2012). Current therapy and future perspectives for inflammation-associated cancer. In: From Inflammation to Cancer: Advances in Diagnosis and Therapy for Gastrointestinal and Hepatological Diseases. C.H. Cho & J. Yu (Editors). World Scientific, Singapore, 17: 351-356.
  • Chan RLY, Zhang L, Leung PL, Cho CH (2012). Osteoporosis and Cigarette Smoking: The Association and Future. Adaptive Medicine 4(2):57-63.
2011
  • Ye CG, Wu WKK, Yeung JH, Li HT, Li ZJ, Wong CCM, Ren SX, Zhang L, Fung KP, Cho CH (2011). Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein and MRP1 expression. Cancer Lett 28; 304(2):90-96.
  • Wong CCM, Zhang L, Ren SX, Shen J, Chan RLY, Cho CH (2011). Antibacterial peptides and gastrointestinal disease. Curr Pharm Des 17(16):1583-1586.
2010
  • Li ZJ, Wu WKK, Ng SS, Yu L, Li HT, Wong CCM, Wu YC, Zhang L, Ren SX, Sun XG, Chan KM, Cho CH (2010). A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery. J Control Release 20; 148(3): 292-302.
  • Wu WKK, Wong CCM, Li ZJ, Zhang L, Ren SX, Cho CH (2010). Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders. Acta Pharmacol Sin 31(9):1118-1122.
  • Wu WKK, Cho CH, Lee C, Wu YC, Yu L, Li ZJ, Wong CCM, Li HT, Zhang L, Ren SX, Che CT, Yu J, Sung JJY (2010). Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy 6, 1-11.

As first, ^co-first, *corresponding author or senior author

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