Faculty of Medicine,
The Chinese University of Hong Kong

Prof. LING Lowell

PROFESSOR

Prof. LING Lowell

LMCHK, MBBS (UK), MPhil (Cantab), MRCP (UK), FHKCA (IC), FHKAM (Anaes), FCICM

Assistant Professor
Department of Anaesthesia and Intensive Care
The Chinese University of Hong Kong

Assistant Professor
Intensive Care Unit
Prince of Wales Hospital

My research interests are in sepsis, organ dysfunction and critical care. I am currently researching on epidemiology of sepsis in Hong Kong and using genomic approaches to understand sepsis. I am a steering committee member of Asian Pacific Sepsis Alliance and serve on the editorial board of Journal of Intensive Care.

For more details about my academic profile, see: https://orcid.org/0000-0001-6639-7344

Prof. LING Lowell

Publications

For a list of my publications and citations please refer to:
http://www.researcherid.com/rid/C-7606-2009 (Researcher ID:C-7606-2009)

  • Li A, Ling L, Qin H, Arabi YM, Myatra SN, Egi M, Kim JH, Nor MBM, Son DN, Fang WF, Wahyuprajitno B, Hashmi M, Faruq MO, Patjanasoontorn B, Al Bahrani MJ, Shrestha BR, Shrestha U, Nafees KMK, Sann KK, Palo JEM, Mendsaikhan N, Konkayev A, Detleuxay K, Chan YH, Du B, Divatia JV, Koh Y, Phua J, Group MIS, Asian Critical Care Clinical Trials G. Prognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings. Crit Care. 2024;28(1):30.
 
  • Phua J, Kulkarni AP, Mizota T, Hashemian SMR, Lee WY, Permpikul C, Chittawatanarat K, Nitikaroon P, Arabi YM, Fang WF, Konkayev A, Hashmi M, Palo JE, Faruq MO, Shrestha BR, Kc B, Mat Nor MBB, Sann KK, Ling L, Haniffa R, Al Bahrani M, Mendsaikhan N, Chan YH, Asian Critical Care Clinical Trials G. Critical care bed capacity in Asian countries and regions before and during the COVID-19 pandemic: an observational study. Lancet Reg Health West Pac. 2024;44:100982.
 
  • Chen Z, Ng RWY, Lui G, Ling L, Leung ASY, Chow C, Boon SS, Ho WCS, Wang MH, Chan RWY, Li AM, Hui DSC, Chan PKS. Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G. Virologica Sinica. 2024.
 
  • Huang B, Huang J, Chiang NH, Chen Z, Lui G, Ling L, Kwan MYW, Wong JSC, Mak PQ, Ling JWH, Lam ICS, Ng RWY, Wang X, Gao R, Hui DS, Ma SL, Chan PKS, Tang NLS. Interferon response and profiling of interferon response genes in peripheral blood of vaccine-naive COVID-19 patients. Front Immunol. 2023;14:1315602.
 
  • Li Q, Chen Z, Zhang Y, Chan RWY, Chong MKC, Zee BCY, Ling L, Lui G, Chan PKS, Wang MH. Genetic association of COVID-19 severe versus non-severe cases by RNA sequencing in patients hospitalised in Hong Kong. Hong Kong Med J. 2024;30(1):25-31.
 
  • Boos J, van der Made CI, Ramakrishnan G, Coughlan E, Asselta R, Loscher BS, Valenti LVC, de Cid R, Bujanda L, Julia A, Pairo-Castineira E, Baillie JK, May S, Zametica B, Heggemann J, Albillos A, Banales JM, Barretina J, Blay N, Bonfanti P, Buti M, Fernandez J, Marsal S, Prati D, Ronzoni L, Sacchi N, Spanish/Italian Severe C-Sg, Gen OI, Schultze JL, Riess O, Franke A, Rawlik K, Ellinghaus D, Hoischen A, Schmidt A, Ludwig KU. Stratified analyses refine association between TLR7 rare variants and severe COVID-19. HGG Adv. 2024;5(4):100323.
 
  • Mok BW, Kwok M, Li HS, Ling L, Lai A, Yan B, Law CT, Yeung CH, Zhang AJ, Tam RC, Kukic A, Cremin CJ, Zhang Y, Long T, Kang Z, Luo R, Leung KT, Li AM, Lui G, Tsui SK, Chan JF, To KK, Chan PKS, Yan BP, Chen H, Poon EN. SARS-CoV-2 variants divergently infect and damage cardiomyocytes in vitro and in vivo. Cell Biosci. 2024;14(1):101.
 
  • Williams P, Cotta MO, Tabah A, Sandaradura I, Kanji S, Scheetz MH, Imani S, Elhadi M, Pardos SL, Schellack N, Sanches C, Timsit JF, Xie J, Farkas A, Wilks K, Roberts JA, National C, European Society of Intensive Care M, the European Society of Clinical M, Infectious Diseases Study Group for Infections in Critically Ill P. Antimicrobial therapeutic drug monitoring in critically ill adult patients – An international perspective on access, utilisation, and barriers. Int J Antimicrob Agents. 2024;64(2):107192.
 
  • Chen Z, Fung E, Wong CK, Ling L, Lui G, Lai CKC, Ng RWY, Sze RKH, Ho WCS, Hui DSC, Chan PKS. Early Metabolomic and Immunologic Biomarkers as Prognostic Indicators for COVID-19. Metabolites. 2024;14(7).
 
  • Tang E, Chan AK, Ling L. Effect of Fasting Prior to Extubation on Prevalence of Empty Stomach in Enterally Fed and Mechanically Ventilated Patients. Respiratory care. 2024.
 
  • Lau CH, Ling L, Zhang JZ, Ng PY, Chan CY, Yeung AWT, Fong KM, Chan JKH, Au GKF, Liong T, Dharmangadan M, Chow FL, Lam KN, Chan KM, Ling S, Lee A. Association between time to surgery and hospital mortality in patients with community-acquired limb necrotizing fasciitis: an 11-year multicenter retrospective cohort analysis. BMC Infect Dis. 2024;24(1):624.
 
  • Chen H, Liu W, Coker OO, Qin N, Chen H, Wang Y, Liu X, Zhang L, Choi GYS, Wong WT, Leung CCH, Ling L, Hui M, Gin T, Wong SH, Chan MTV, Wu WKK. Blood microbial signatures associated with mortality in patients with sepsis: A pilot study. Heliyon. 2024;10(8):e29572.
 
  • Gomersall ELM, Ling L, Reinhart K, Bion V, Ekesh A, Adu-Takyi C, Azevedo LCP, Banguti PR, Cohen J, Diaz JV, Du B, Goldfarb DM, Gorordo-Delsol LA, Graham CA, Iramain R, Jacob ST, Kecskes Z, Kissoon N, Lipman J, Lundeg G, Maitland K, Mergani KO, Moschides C, Nakalembe M, Ndu IK, Oon J, Sale T, Shresthra A, Stockley S, Talmor D, Tse AB, Zachariah A, Joynt GM. Core sepsis-related competencies for medical students: an international consensus by Delphi technique. BMC Med Educ. 2024;24(1):653.
  • Gao X, Chan PK, Wong KC, Ng RW, Yeung AC, Lui GC, Ling L, Hui DS, Huang D, Wong CK. Characterization of METRNbeta as a novel biomarker of Coronavirus disease 2019 severity and prognosis. Front Immunol. 2023;14:1111920.
 
  • Ling L, Zhang JZ, Chang LC, Chiu LCS, Ho S, Ng PY, Dharmangadan M, Lau CH, Ling S, Man MY, Fong KM, Liong T, Yeung AWT, Au GKF, Chan JKH, Tang M, Liu YZ, Wu WKK, Wong WT, Wu P, Cowling BJ, Lee A, Rhee C. Population sepsis incidence, mortality, and trends in Hong Kong between 2009-2018 using clinical and administrative data. Clin Infect Dis. 2023.
 
  • Initiative C-HG. A second update on mapping the human genetic architecture of COVID-19. Nature. 2023;621(7977):E7-E26.
 
  • So C, Ling L, Wong WT, Zhang JZ, Ho CM, Ng PY, Shum HP, Yeung AWT, Sin KC, Chan J, Au KF, Liong T, Ho E, Chow FL, Ho L, Chan KM, Joynt GM. Population study on diagnosis, treatment and outcomes of critically ill patients with tuberculosis in Hong Kong (2008-2018). Thorax. 2022.
 
  • Chu RBH, Zhao S, Zhang JZ, Chan KCK, Ng PY, Chan C, Fong KM, Au SY, Yeung AWT, Chan JKH, Tsang HH, Law KI, Chow FL, Lam KN, Chan KM, Dharmangadan M, Wong WT, Joynt GM, Wang MH, Ling L. Comparison of COVID-19 with influenza A in the ICU: a territory-wide, retrospective, propensity matched cohort on mortality and length of stay. BMJ Open. 2023;13(7):e067101.
 
  • Ng RWY, Sze RKH, Chong KC, Zhao S, Ling L, Lui G, Leung ASY, Yeung ACM, Ho WCS, Wong MCS, Chen Z, Boon SS, Hui DSC, Chan PKS. Effectiveness of mRNA and inactivated COVID-19 vaccines: A test-negative study in an infection-naive Hong Kong population. J Infect. 2023;87(2):136-43.
 
  • Joynt GM, Ling L, Wong WT, Lipman J. Therapeutic drug monitoring of carbapenem antibiotics in critically ill patients: an overview of principles, recommended dosing regimens, and clinical outcomes. Expert Rev Clin Pharmacol. 2023;16(8):703-14.
 
  • Ling L, Lai CKC, Lui G, Yeung ACM, Chan HC, Cheuk CHS, Cheung AN, Chang LC, Chiu LCS, Zhang JZ, Wong WT, Hui DSC, Wong CK, Chan PKS, Chen Z. Characterization of upper airway microbiome across severity of COVID-19 during hospitalization and treatment. Front Cell Infect Microbiol. 2023;13:1205401.
 
  • Ng PY, Chan VWS, Ip A, Ling L, Chan KM, Leung AKH, Chan KKC, So D, Shum HP, Ngai CW, Chan WM, Sin WC. Ten-year territory-wide trends in the utilisation and clinical outcomes of extracorporeal membrane oxygenation in Hong Kong. Hong Kong Med J. 2023;29(6):514-23.
 
  • Ho KM, Lee A, Wu W, Chan MTV, Ling L, Lipman J, Roberts J, Litton E, Joynt GM, Wong M. Flattening the biological age curve by improving metabolic health: to taurine or not to taurine, that’ s the question. J Geriatr Cardiol. 2023;20(11):813-23.
 
  • Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A, Richmond A, Millar J, Russell CD, Malinauskas T, Thwaites R, Morrice K, Keating S, Maslove D, Nichol A, Semple MG, Knight J, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Begg C, Walsh T, Tenesa A, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P, Gen OI, Consortium S, Investigators I, andMe C-T, Yang J, Ponting CP, Wilson JF, Vitart V, Abedalthagafi M, Luchessi AD, Parra EJ, Cruz R, Carracedo A, Fawkes A, Murphy L, Rowan K, Pereira AC, Law A, Fairfax B, Hendry SC, Baillie JK. GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. 2023;617(7962):764-8.
 
  • Park SH, Hong SH, Kim K, Lee SW, Yon DK, Jung SJ, Abdeen Z, Ghayda RA, Ahmed M, Serouri AA, Al-Herz W, Al-Shamsi HO, Ali S, Ali K, Baatarkhuu O, Nielsen HB, Bernini-Carri E, Bondarenko A, Cassell A, Cham A, Chua MLK, Dadabhai S, Darre T, Davtyan H, Dragioti E, East B, Edwards RJ, Ferioli M, Georgiev T, Ghandour LA, Harapan H, Hsueh PR, Mallah SI, Ikram A, Inoue S, Jacob L, Jankovic SM, Jayarajah U, Jesenak M, Kakodkar P, Kapata N, Kebede Y, Khader Y, Kifle M, Koh D, Males VK, Kotfis K, Koyanagi A, Kretchy JP, Lakoh S, Lee J, Lee JY, Mendonca M, Ling L, Llibre-Guerra J, Machida M, Makurumidze R, Memish ZA, Mendoza I, Moiseev S, Nadasdy T, Nahshon C, Namendys-Silva SA, Yongsi BN, Nicolasora AD, Nugmanova Z, Oh H, Oksanen A, Owopetu O, Ozguler ZO, Parperis K, Perez GE, Pongpirul K, Rademaker M, Radojevic N, Roca A, Rodriguez-Morales AJ, Roshi E, Saeed KMI, Sah R, Sakakushev B, Sallam DE, Sathian B, Schober P, Ali PSS, Simonovic Z, Singhal T, Skhvitaridze N, Solmi M, Subbaram K, Tizaoui K, Tlhakanelo JT, Torales J, Torres-Roman JS, Tsartsalis D, Tsolmon J, Vieira DN, Rosa SGV, Wanghi G, Wollina U, Xu RH, Yang L, Zia K, Zildzic M, Il Shin J, Smith L. Nonpharmaceutical interventions reduce the incidence and mortality of COVID-19: A study based on the survey from the International COVID-19 Research Network (ICRN). J Med Virol. 2023;95(2):e28354.
  • Ling L, Chen Z, Lui G, Wong CK, Wong WT, Ng RWY, Tso EYK, Fung KSC, Chan V, Yeung ACM, Hui DSC, Chan PKS. Longitudinal Cytokine Profile in Patients With Mild to Critical COVID-19. Front Immunol. 2021;12:763292.
 
  • Abou Ghayda R, Lee KH, Han YJ, Ryu S, Hong SH, Yoon S, Jeong GH, Yang JW, Lee HJ, Lee J, Lee JY, Effenberger M, Eisenhut M, Kronbichler A, Solmi M, Li H, Jacob L, Koyanagi A, Radua J, Park MB, Aghayeva S, Ahmed M, Al Serouri A, Al-Shamsi HO, Amir-Behghadami M, Baatarkhuu O, Bashour H, Bondarenko A, Camacho-Ortiz A, Castro F, Cox H, Davtyan H, Douglas K, Dragioti E, Ebrahim S, Ferioli M, Harapan H, Mallah SI, Ikram A, Inoue S, Jankovic S, Jayarajah U, Jesenak M, Kakodkar P, Kebede Y, Kifle M, Koh D, Males VK, Kotfis K, Lakoh S, Ling L, Llibre-Guerra J, Machida M, Makurumidze R, Mamun MA, Masic I, Van Minh H, Moiseev S, Nadasdy T, Nahshon C, Namendys-Silva SA, Yongsi BN, Nielsen HB, Nodjikouambaye ZA, Ohnmar O, Oksanen A, Owopetu O, Parperis K, Perez GE, Pongpirul K, Rademaker M, Rosa S, Sah R, Sallam D, Schober P, Singhal T, Tafaj S, Torres I, Torres-Roman JS, Tsartsalis D, Tsolmon J, Tuychiev L, Vukcevic B, Wanghi G, Wollina U, Xu RH, Yang L, Zaidi Z, Smith L, Shin JI. The global case fatality rate of coronavirus disease 2019 by continents and national income: A meta-analysis. J Med Virol. 2022;94(6):2402-13.
 
  • Ling L, Wong WT, Lipman J, Joynt GM. A Narrative Review on the Approach to Antimicrobial Use in Ventilated Patients with Multidrug Resistant Organisms in Respiratory Samples-To Treat or Not to Treat? That Is the Question. Antibiotics (Basel). 2022;11(4).
 
  • Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A, Gen Oi, andMe i, Initiative C-HG, Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK. Whole-genome sequencing reveals host factors underlying critical COVID-19. Nature. 2022;607(7917):97-103.
 
  • Chan KM, Wan WTP, Ling L, So JMC, Wong CHL, Tam SBS. Management of Circuit Air in Extracorporeal Membrane Oxygenation: A Single Center Experience. ASAIO J. 2022;68(3):e39-e43.
 
  • Ling L, Mui OOY, Laupland KB, Lefrant JY, Roberts JA, Gopalan PD, Lipman J, Joynt GM, CaBo OMi. Scoping review on diagnostic criteria and investigative approach in sepsis of unknown origin in critically ill patients. J Intensive Care. 2022;10(1):44.
 
  • Lai CK, Lui GC, Wei Y, Chong KC, Chen Z, Ling L, Ng RW, Boon SS, Ho WC, Yeung AC, Hui DS, Chan PK. Remdesivir reduced upper respiratory tract SARS-CoV-2 viral RNA concentration in COVID-19 patients who developed pneumonitis. J Infect. 2022;85(6):702-69.
 
  • Li A, Ling L, Qin H, Arabi YM, Myatra SN, Egi M, Kim JH, Mat Nor MB, Son DN, Fang WF, Wahyuprajitno B, Hashmi M, Faruq MO, Patjanasoontorn B, Al Bahrani MJ, Shrestha BR, Shrestha U, Nafees KMK, Sann KK, Palo JEM, Mendsaikhan N, Konkayev A, Detleuxay K, Chan YH, Du B, Divatia JV, Koh Y, Gomersall CD, Phua J. Epidemiology, Management, and Outcomes of Sepsis in ICUs among Countries of Differing National Wealth across Asia. Am J Respir Crit Care Med. 2022;206(9):1107-16.
 
  • Chen Z, Ng RWY, Lui G, Ling L, Chow C, Yeung ACM, Boon SS, Wang MH, Chan KCC, Chan RWY, Hui DSC, Chan PKS. Profiling of SARS-CoV-2 Subgenomic RNAs in Clinical Specimens. Microbiol Spectr. 2022;10(2):e0018222.
 
  • Ng PY, Ip A, Fang S, Lin JCR, Ling L, Chan KM, Leung KHA, Chan KCK, So D, Shum HP, Ngai CW, Chan WM, Sin WC. Effect of hospital case volume on clinical outcomes of patients requiring extracorporeal membrane oxygenation: a territory-wide longitudinal observational study. J Thorac Dis. 2022;14(6):1802-14.
 
  • Wang G, Lam WKJ, Ling L, Ma ML, Ramakrishnan S, Chan DCT, Lee WS, Cheng SH, Chan RWY, Yu SCY, Tse IOL, Wong WT, Jiang P, Chiu RWK, Allen Chan KC, Lo YMD. Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis. Clin Chem. 2023;69(2):189-201.
 
  • Ng PY, Chan HCV, Ip A, Ling L, Chan KM, Leung KHA, Chan KCK, So D, Shum HP, Ngai CW, Chan WM, Sin WC. Restrictive and liberal transfusion strategies in extracorporeal membrane oxygenation: A retrospective observational study. Transfusion. 2023;63(2):294-304.
 
  • Lai CKC, Cheung MK, Lui GCY, Ling L, Chan JYK, Ng RWY, Chan HC, Yeung ACM, Ho WCS, Boon SS, Chan PKS, Chen Z. Limited Impact of SARS-CoV-2 on the Human Naso-Oropharyngeal Microbiota in Hospitalized Patients. Microbiol Spectr. 2022;10(6):e0219622.
 
  • Li KH, Yeung DC, Ling L. The effect of ethanol immersion on fit performance and comfort of a fit tested reusable mask. Journal of Industrial Textiles. 2022;52:15280837221123061.
 
  • Kumar A, Abbenbroek B, Hammond N, Vijayaraghavan BKT, Ling L, Thwaites L, Myatra SN, Finfer S. Critical care resources, disaster preparedness, and sepsis management: Survey results from the Asia Pacific region. Journal of Hospital Administration. 2022;11(1):23-34.
  • Ling L, Ho CM, Ng PY, Chan KCK, Shum HP, Chan CY, Yeung AWT, Wong WT, Au SY, Leung KHA, Chan JKH, Ching CK, Tam OY, Tsang HH, Liong T, Law KI, Dharmangadan M, So D, Chow FL, Chan WM, Lam KN, Chan KM, Mok OF, To MY, Yau SY, Chan C, Lei E, Joynt GM. Characteristics and outcomes of patients admitted to adult intensive care units in Hong Kong: a population retrospective cohort study from 2008 to 2018. J Intensive Care. 2021;9(1):2.
 
  • Yeoh YK, Zuo T, Lui GC, Zhang F, Liu Q, Li AY, Chung AC, Cheung CP, Tso EY, Fung KS, Chan V, Ling L, Joynt G, Hui DS, Chow KM, Ng SSS, Li TC, Ng RW, Yip TC, Wong GL, Chan FK, Wong CK, Chan PK, Ng SC. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut. 2021;70(4):698-706.
 
  • Ling L, Joynt GM, Lipman J. A narrative review on antimicrobial therapy in septic shock: updates and controversies. Curr Opin Anaesthesiol. 2021;34(2):92-8.
 
  • Kwak GH, Ling L, Hui P. Predicting the Need For Vasopressors in the Intensive Care Unit Using an Attention Based Deep Learning Model. Shock. 2021;56(1):73-9.
 
  • Kwak GH, Ling L, Hui P. Deep reinforcement learning approaches for global public health strategies for COVID-19 pandemic. PLoS One. 2021;16(5):e0251550.
 
  • Zuo T, Liu Q, Zhang F, Yeoh YK, Wan Y, Zhan H, Lui GCY, Chen Z, Li AYL, Cheung CP, Chen N, Lv W, Ng RWY, Tso EYK, Fung KSC, Chan V, Ling L, Joynt G, Hui DSC, Chan FKL, Chan PKS, Ng SC. Temporal landscape of human gut RNA and DNA virome in SARS-CoV-2 infection and severity. Microbiome. 2021;9(1):91.
 
  • Siu BMK, Kwak GH, Ling L, Hui P. Predicting the need for intubation in the first 24 h after critical care admission using machine learning approaches. Sci Rep. 2020;10(1):20931.
 
  • Wong WT, Lee A, Gomersall CD, Shek LH, Chan A, So SO, Sin KC, Tang WM, Sinn M, Ling L. Survival of mechanically ventilated ward patients and association with organisational factors: a multicentre prospective study. BMJ Open. 2021;11(12):e052462.
 
  • Phua J, Lim CM, Faruq MO, Nafees KMK, Du B, Gomersall CD, Ling L, Divatia JV, Hashemian SMR, Egi M, Konkayev A, Mat-Nor MB, Shrestha GS, Hashmi M, Palo JEM, Arabi YM, Tan HL, Dissanayake R, Chan MC, Permpikul C, Patjanasoontorn B, Son DN, Nishimura M, Koh Y, Asian Critical Care Clinical Trials G. The story of critical care in Asia: a narrative review. J Intensive Care. 2021;9(1):60.
 
  • Cao L, Zhao S, Li Q, Ling L, Wu WKK, Zhang L, Lou J, Chong MKC, Chen Z, Wong ELY, Zee BCY, Chan MTV, Chan PKS, Wang MH. A Bayesian method for synthesizing multiple diagnostic outcomes of COVID-19 tests. R Soc Open Sci. 2021;8(9):201867.
 
  • Tong SK, Ling L, Zhang JZ, Yap FHY, Law KL, Joynt GM. Effect of the COVID-19 pandemic on cardiac arrest resuscitation practices and outcomes in non-COVID-19 patients. J Intensive Care. 2021;9(1):55.
 
  • Liu Y, Ling L, Wong SH, Wang MH, Fitzgerald JR, Zou X, Fang S, Liu X, Wang X, Hu W, Chan H, Wang Y, Huang D, Li Q, Wong WT, Choi G, Zou H, Hui DS, Yu J, Tse G, Gin T, Wu WK, Chan MT, Zhang L. Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients. EClinicalMedicine. 2021;37:100955.
 
  • Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, Nichol A, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira AC, Renieri A, Gen OI, Investigators IC, Initiative C-HG, andMe I, Investigators B, Gen CI, Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK. Genetic mechanisms of critical illness in COVID-19. Nature. 2021;591(7848):92-8.
  • Phua J, Weng L, Ling L, Egi M, Lim CM, Divatia JV, Shrestha BR, Arabi YM, Ng J, Gomersall CD, Nishimura M, Koh Y, Du B, Asian Critical Care Clinical Trials G. Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Lancet Respir Med. 2020;8(5):506-17.
 
  • Ling L, Joynt GM, Lipman J, Constantin JM, Joannes-Boyau O. COVID-19: A critical care perspective informed by lessons learnt from other viral epidemics. Anaesth Crit Care Pain Med. 2020;39(2):163-6.
 
  • Ling L, So C, Shum HP, Chan PKS, Lai CKC, Kandamby DH, Ho E, So D, Yan WW, Lui G, Leung WS, Chan MC, Gomersall CD. Critically ill patients with COVID-19 in Hong Kong: a multicentre retrospective observational cohort study. Crit Care Resusc. 2020;22(2):119-25.
 
  • Phua J, Faruq MO, Kulkarni AP, Redjeki IS, Detleuxay K, Mendsaikhan N, Sann KK, Shrestha BR, Hashmi M, Palo JEM, Haniffa R, Wang C, Hashemian SMR, Konkayev A, Mat Nor MB, Patjanasoontorn B, Nafees KMK, Ling L, Nishimura M, Al Bahrani MJ, Arabi YM, Lim CM, Fang WF, Asian Analysis of Bed Capacity in Critical Care Study I, the Asian Critical Care Clinical Trials G. Critical Care Bed Capacity in Asian Countries and Regions. Crit Care Med. 2020;48(5):654-62.
 
  • Ho J, Chan H, Liang Y, Liu X, Zhang L, Li Q, Zhang Y, Zeng J, Ugwu FN, Ho IHT, Hu W, Yau JCW, Wong SH, Wong WT, Ling L, Cho CH, Gallo RL, Gin T, Tse G, Yu J, Chan MTV, Leung CCH, Wu WKK. Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. Crit Care. 2020;24(1):47.
 
  • Ling L, Wong WT, Wan WTP, Choi G, Joynt GM. Infection control in non-clinical areas during the COVID-19 pandemic. Anaesthesia. 2020;75(7):962-3.
 
  • Lui G, Ling L, Lai CK, Tso EY, Fung KS, Chan V, Ho TH, Luk F, Chen Z, Ng JK, Chow KM, Cheng PK, Chan RC, Tsang DN, Gomersall CD, Hui DS, Chan PK. Viral dynamics of SARS-CoV-2 across a spectrum of disease severity in COVID-19. J Infect. 2020;81(2):318-56.
 
  • Zuo T, Zhang F, Lui GCY, Yeoh YK, Li AYL, Zhan H, Wan Y, Chung ACK, Cheung CP, Chen N, Lai CKC, Chen Z, Tso EYK, Fung KSC, Chan V, Ling L, Joynt G, Hui DSC, Chan FKL, Chan PKS, Ng SC. Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization. Gastroenterology. 2020;159(3):944-55 e8.
 
  • group Icc. Global outbreak research: harmony not hegemony. Lancet Infect Dis. 2020;20(7):770-2.
 
  • Lai CKC, Chen Z, Lui G, Ling L, Li T, Wong MCS, Ng RWY, Tso EYK, Ho T, Fung KSC, Ng ST, Wong BKC, Boon SS, Hui DSC, Chan PKS. Prospective Study Comparing Deep Throat Saliva With Other Respiratory Tract Specimens in the Diagnosis of Novel Coronavirus Disease 2019. J Infect Dis. 2020;222(10):1612-9.
 
  • Liu YZ, Chu R, Lee A, Gomersall CD, Zhang L, Gin T, Chan MTV, Wu WKK, Ling L. A surveillance method to identify patients with sepsis from electronic health records in Hong Kong: a single centre retrospective study. BMC Infect Dis. 2020;20(1):652.
  • Ng WT, Ling L, Joynt GM, Chan KM. An audit of mortality by using ECMO specific scores and APACHE II scoring system in patients receiving extracorporeal membrane oxygenation in a tertiary intensive care unit in Hong Kong. J Thorac Dis. 2019;11(2):445-55.
  • Leung CCH, Joynt GM, Gomersall CD, Wong WT, Lee A, Ling L, Chan PKS, Lui PCW, Tsoi PCY, Ling CM, Hui M. Comparison of high-flow nasal cannula versus oxygen face mask for environmental bacterial contamination in critically ill pneumonia patients: a randomized controlled crossover trial. J Hosp Infect. 2019;101(1):84-7.
  • Ling L, Chan KM. Weaning adult patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation by pump-controlled retrograde trial off. Perfusion. 2018;33(5):339-45.
 
  • Joynt GM, Wong WT, Ling L, Lee A. Medical students and professionalism – Do the hidden curriculum and current role models fail our future doctors? Med Teach. 2018;40(4):395-9.
 
  • Tse AHW, Ling L, Lee A, Joynt GM. Altered Pharmacokinetics in Prolonged Infusions of Sedatives and Analgesics Among Adult Critically Ill Patients: A Systematic Review. Clin Ther. 2018;40(9):1598-615 e2.
  • Tse AH, Ling L, Joynt GM, Lee A. Prolonged infusion of sedatives and analgesics in adult intensive care patients: A systematic review of pharmacokinetic data reporting and quality of evidence. Pharmacol Res. 2017;117:156-65.
  • Ling L, Gomersall CD, Samy W, Joynt GM, Leung C, Wong WT, Lee A. The Effect of a Freely Available Flipped Classroom Course on Health Care Worker Patient Safety Culture: A Prospective Controlled Study. J Med Internet Res. 2016;18(7):e180.
2015
  • Ling L, Joynt G, Lee A, Samy W, Fung H, Gomersall CD. Prospective controlled study to compare the effects of a basic patient safety course on healthcare worker patient safety culture. Critical Care. 2015;19(Suppl 1):P514.
  2013
  • Ling L, Maguire JJ, Davenport AP. Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer. Br J Pharmacol. 2013;168(2):283-95.
  2012
  • Ling L, Kuc RE, Maguire JJ, Davie NJ, Webb DJ, Gibbs P, Alexander GJ, Davenport AP. Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice. Life Sci. 2012;91(13-14):716-22.
  2010
  • Mahony O, Tsigkou O, Ionescu C, Minelli C, Ling L, Hanly R, Smith ME, Stevens MM, Jones JR. Silica-Gelatin Hybrids with Tailorable Degradation and Mechanical Properties for Tissue Regeneration. Adv Funct Mater. 2010;20(22):3835-45.

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Last updated on 26-09-2024