The Dept of Anaesthesia & Intensive Care, CUHK thanks

for an unrestricted education grant
BASIC instructor/provider course, Hong Kong, July 2nd-4th
Other upcoming courses
Home Feedback Contents

Metoclopramide

Up ACE inhibitors Adenosine Anaphylaxis Antiarrhythmics Antibacterials Anticoagulants Anti-fibrinolytics Antifungals Antiplatelet drugs Anti-virals Beta2 agonists Ca antagonists Corticosteroids Erythropoietin Fosphenytoin Hydralazine Immunosuppressants Inotropes & vasopressors Insulin IV immunoglobulin Labetalol Mannitol Metoclopramide N-acetylcysteine Nesiritide Neuroleptic malignant syn Nitric oxide Nitroprusside Proton pump inhibitors Sedatives Serotonin syndrome Sucralfate Suxamethonium Theophylline Vasopressin


Metoclopramide

Mode of action

- lowers pressure threshold for occurrence of intestinal peristaltic reflex
- reduces intestinal muscle fatigue
- enhances frequency and amplitude of longitudinal muscle contraction
- coordinates gastric, pyloric and duodenal activity to improve GI motility
- mechanism of action appears to depend on intramural cholinergic neurons. Appears that acts primarily by augmenting release of ACh and perhaps by inhibition of 5-HT release
- increases lower oesophageal sphincter pressure

Often used to enhance gastric emptying in patients with high gastric residual volume who are receiving gastric feeding.

Contraindicated in children <18 years due to an increased risk of neurological adverse effects, especially extrapyramidal syndromes


© Charles Gomersall December 1999

 

©Charles Gomersall, April, 2014 unless otherwise stated. The author, editor and The Chinese University of Hong Kong take no responsibility for any adverse event resulting from the use of this webpage.
Copyright policy    Contributors