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Up Blood transfusion DIC Haemophagocytic TTP & HUS HIT

Haemophagocytic syndromes

Clinical manifestation of an increased macrophagic activity with haemophagocytosis.


  • Familial

  • Acquired

    • Infection

      • EBV

      • Bacterial, fungal and parasitic infections

    • Associated with immunodeficiency, haematological malignancies, auto-immune disease


  • deregulation of T-lymphocytes

  • excessive production of cytokines

Clinical features

  • Fever

  • Hepatosplenomegaly

  • Lymphadenopathy

  • Skin rash

  • Neurological features

  • Anaemia, lymphopaenia, thrombocytopaenia

  • Hypertriglyceridaemia

  • Hyperferritinaemia

  • Coagulopathy


Bone marrow: benign histiocytes actively phagocytosing haemopoietic cells


  • Treat underlying disease

  • Cytotoxic therapy may help


©Charles Gomersall, April, 2014 unless otherwise stated. The author, editor and The Chinese University of Hong Kong take no responsibility for any adverse event resulting from the use of this webpage.
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