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Up Candida laryngitis Candida peritonitis Candida pneumonia Candiduria in critically ill Prophylaxis

Updated August 2009 by Charles Gomersall

  • Meta-analysis suggests that prophylaxis with fluconzale decreases risk of invasive candidiasis and prophylaxis with fluconazole or ketoconazole reduces mortality. Problem is that this data gives no guidance regarding which patients should receive prophylaxis
  • expert opinion is that antifungal prophylaxis may be warranted in ICUs with very high rates of invasive candidiasis (compared with "normal" rates of 1-2% of patients). This should be given to patients with the highest (>10%) risk of invasive candidiasis

Further reading

Pappas PG. Guidelines for treatment of candidiasis: 2009 update by Infectious Diseases Society of Ameria. Clin Infect Dis 2009; 48:503-535

Potential conflict of interest

The Dept of Anaesthesia & Intensive Care, Chinese University of Hong Kong has received educational grants and payment for research from Pfizer Corporation Hong Kong Ltd and educational grants from Merck Sharp & Dohme.

Dr Gomersall has received a speaker's honorarium from Pfizer Corporation

©Charles Gomersall, April, 2014 unless otherwise stated. The author, editor and The Chinese University of Hong Kong take no responsibility for any adverse event resulting from the use of this webpage.
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