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Metoclopramide

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Metoclopramide

Mode of action

- lowers pressure threshold for occurrence of intestinal peristaltic reflex
- reduces intestinal muscle fatigue
- enhances frequency and amplitude of longitudinal muscle contraction
- coordinates gastric, pyloric and duodenal activity to improve GI motility
- mechanism of action appears to depend on intramural cholinergic neurons. Appears that acts primarily by augmenting release of ACh and perhaps by inhibition of 5-HT release
- increases lower oesophageal sphincter pressure

© Charles Gomersall December 1999

 

©Charles Gomersall, October, 2009 unless otherwise stated. The author, editor and The Chinese University of Hong Kong take no responsibility for any adverse event resulting from the use of this webpage.
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