Home Feedback Contents

Lincosamides

Up Aminoglycosides Beta-lactams Daptomycin Glycopeptides Lincosamides Linezolid Macrolides Polymyxins Quinolones Streptogramins Dosing in renal failure

Asian Intensive Care: coming of age
International intensive care conference, Hong Kong, December 14th-15th
Register now!
Click here for details

 

Lincosamides

Lincomycin

Clindamycin

Mode of action

  • bind to 50S subunit of bacterial ribosomes
  • similar action to macrolides
  • inhibit early elongation of peptide chain by inhibiting transpeptidase reaction

Resistance

  • alteration of target site. Similar to resistance found in macrolides and streptogramins
  • enzymatic inactivation of clindamycin has been described (rare)

Pharmacodynamics

Further reading

Van Bambeke F. Mechanisms of action. In Armstrong D, Cohen J. Infectious diseases. Mosby, London, 1999, pp7/1.1-7/1.14

 

©Charles Gomersall, October, 2009 unless otherwise stated. The author, editor and The Chinese University of Hong Kong take no responsibility for any adverse event resulting from the use of this webpage.
Copyright policy    Contributors