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Lincosamides

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Lincosamides

Lincomycin

Clindamycin

Mode of action

  • bind to 50S subunit of bacterial ribosomes
  • similar action to macrolides
  • inhibit early elongation of peptide chain by inhibiting transpeptidase reaction

Resistance

  • alteration of target site. Similar to resistance found in macrolides and streptogramins
  • enzymatic inactivation of clindamycin has been described (rare)

Pharmacodynamics

Further reading

Van Bambeke F. Mechanisms of action. In Armstrong D, Cohen J. Infectious diseases. Mosby, London, 1999, pp7/1.1-7/1.14

 


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