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Dextropropoxyphene

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  • opioid effects
  • inhibits cardiac membrane sodium conduction
  • onset of clinical features is rapid

Clinical features

CVS

  • QRS or QT prolongation
  • ventricular dysrhythmias
  • conduction defects
  • hypotension

RS

  • respiratory depression

GI

  • nausea, vomiting, anorexia
  • abdominal pain
  • constipation

CNS

  • drowsiness, coma
  • confusion, hallucinations
  • seizures
  • miosis

Endocrine

  • nephrogenic DI (rare)

Treatment

Benzodiazepines for seizures resistant to naloxone

©Charles Gomersall, October, 2009 unless otherwise stated. The author, editor and The Chinese University of Hong Kong take no responsibility for any adverse event resulting from the use of this webpage.
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