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Cephalosporins

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Cephalosporins

Spectrum of activity

Generation Example Antimicrobial spectrum

1st

Cephradine

Gm +ve cocci, some community acquired Gm –ve bacilli

2nd

Cefuroxime, cefoxitin

Improved gm –ve cover compared with 1st generation. Some agents have activity against anaerobes (eg cefoxitin)

3rd

Ceftazidime, ceftriaxone, cefotaxime

Improved Gm –ve cover (cf. 2nd generation). Gm +ve cover variable. Ceftriaxone and cefotaxime have excellent pneumococcal and modest staphylococcal cover while ceftazidime has limited Gm +ve cover (but excellent P. aeruginosa cover).

4th

Cefepime

Excellent Gm+ve and Gm-ve cover (including P. aeruginosa)

 

 

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