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SLEDD

Up Haemodialysis Haemofiltration Peritoneal dialysis SLEDD

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Slow Low Efficiency Daily Dialysis

  • variant of intermittent haemodialysis
  • duration of dialysis 8-12 hours
  • compared to conventional intermittent haemodialysis:
    • lower blood flow
    • fluid removal & solute clearance slower
    • less haemodynamic instability
  • excellent solute control
  • not associated with significant urea dysequilibrium when used over 12 hours
  • commonest complication is clotting of circuit so many patients require anticoagulation:
    • 1000 U unfractionated heparin bolus, followed by 500 U/hour – significant bleeding not reported
  • other complications include:
    • mild hypophosphataemia and hypokalaemia
    • some amino acid loss
    • minimal albumin loss
  • less effective solute clearance than CVVH, particularly for middle and large molecules
  • nocturnal scheduling of SLEDD allows other procedures (eg CT, surgery) to be carried out during the day. Can also free up machine for intermittent haemodialysis during the day
  • less expensive than most CRRT
 

©Charles Gomersall, October, 2009 unless otherwise stated. The author, editor and The Chinese University of Hong Kong take no responsibility for any adverse event resulting from the use of this webpage.
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