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Proton pump inhibitors

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  • adminstration: oral or IV infusion
    • bioavailability ~77%
    • absorption unaffected by food or antacids
  • elimination: completely metabolized by cytochrome P450 with metabolites excreted predominantly in urine
    • t1/2 ~1 hour
  • dosage adjustment not required in elderly and in patients with renal failure
  • t1/2  increased in patients with moderate-severe cirrhosis
  • no clinically significant drug interactions

Adverse effects

  • uncommon (<0.2% of patients)
  • diarrhoea, nausea, vomiting, flatulence
  • headache, vertigo
  • exanthema, urticaria

Further reading

Cheer SM et al. Pantoprazole. An update on its pharmacological properties and therapeutic use in the management of acid-related disorders. Drugs, 2003;63(1):101-32

©Charles Gomersall, April, 2014 unless otherwise stated. The author, editor and The Chinese University of Hong Kong take no responsibility for any adverse event resulting from the use of this webpage.
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