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Penicillium marneffei

Up Immune reconstitution Penicillium marneffei

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Thomas Li

Epidemiology

  • Endemic in South east Asia

  • Reported in Thailand, Indonesia, Hong Kong

  • High mortality

  • 3rd most common opportunistic infection in AIDS patients in Thailand other than extrapulmonary TB and cryptococcosis

Clinical features

  • fever

  • malaise

  • weight loss

  • anaemia

  • lymphadenopathy

  • hepatosplenomegaly

  • bilateral lung infiltrates

  • papules on skin with central umbilication

Diagnosis

Skin , lymph node biopsy, blood culture, bone marrow culture

Treatment

  • IV amphotericin 0.6 mg/kg x 2 weeks

  • Itraconazole 200 mg bd x 6-10 weeks

 © Thomas Li March 2005

©Charles Gomersall, October, 2009 unless otherwise stated. The author, editor and The Chinese University of Hong Kong take no responsibility for any adverse event resulting from the use of this webpage.
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